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SERPINA1 / Alpha 1 Antitrypsin Antibody (clone 48D2)

Mouse Monoclonal Antibody

     
  • WB - SERPINA1 / Alpha 1 Antitrypsin Antibody (clone 48D2) ALS14807
    0
  • IHC - SERPINA1 / Alpha 1 Antitrypsin Antibody (clone 48D2) ALS14807
    Anti-Alpha-1-Antitrypsin antibody IHC of human pancreas.
  • SPECIFICATION
  • CITATIONS
  • PROTOCOLS
  • BACKGROUND
Product Information
Application
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • E=ELISA
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
WB, IHC-P
Primary Accession P01009
Reactivity Human
Host Mouse
Clonality Monoclonal
Clone Names 48D2
Calculated MW 47kDa
Dilution IHC-P (1:400), WB (1:2000),
Additional Information
Gene ID 5265
Other Names Alpha-1-antitrypsin, Alpha-1 protease inhibitor, Alpha-1-antiproteinase, Serpin A1, Short peptide from AAT, SPAAT, SERPINA1, AAT, PI
Reconstitution & Storage Short term 4°C, long term aliquot and store at -20°C, avoid freeze thaw cycles.
PrecautionsSERPINA1 / Alpha 1 Antitrypsin Antibody (clone 48D2) is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Name SERPINA1
Synonyms AAT, PI
Function Inhibitor of serine proteases. Its primary target is elastase, but it also has a moderate affinity for plasmin and thrombin. Irreversibly inhibits trypsin, chymotrypsin and plasminogen activator. The aberrant form inhibits insulin-induced NO synthesis in platelets, decreases coagulation time and has proteolytic activity against insulin and plasmin.
Cellular Location Secreted. Endoplasmic reticulum. Note=The S and Z allele are not secreted effectively and accumulate intracellularly in the endoplasmic reticulum
Tissue Location Ubiquitous. Expressed in leukocytes and plasma.
Volume 50 µl
Research Areas
Citations (0)

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Background

Inhibitor of serine proteases. Its primary target is elastase, but it also has a moderate affinity for plasmin and thrombin. Irreversibly inhibits trypsin, chymotrypsin and plasminogen activator. The aberrant form inhibits insulin-induced NO synthesis in platelets, decreases coagulation time and has proteolytic activity against insulin and plasmin.

References

Bollen A.,et al.DNA 2:255-264(1983).
Long G.L.,et al.Biochemistry 23:4828-4837(1984).
Rosenberg S.,et al.Nature 312:77-80(1984).
Ciliberto G.,et al.Cell 41:531-540(1985).
Nukiwa T.,et al.J. Biol. Chem. 261:15989-15994(1986).

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$ 395.00
Cat# ALS14807
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