|Application ||WB, IHC-P, E|
|Reactivity||Human, Mouse, Rat|
|Dilution||IHC-P (1:400), WB (1:1000),|
|Other Names||MAP kinase-interacting serine/threonine-protein kinase 1, 220.127.116.11, MAP kinase signal-integrating kinase 1, MAPK signal-integrating kinase 1, Mnk1, MKNK1, MNK1|
|Reconstitution & Storage||Short term 4°C, long term aliquot and store at -20°C, avoid freeze thaw cycles.|
|Precautions||MKNK1 / MNK1 Antibody (clone 24C2) is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||May play a role in the response to environmental stress and cytokines. Appears to regulate translation by phosphorylating EIF4E, thus increasing the affinity of this protein for the 7- methylguanosine-containing mRNA cap.|
|Cellular Location||Isoform 2: Cytoplasm.|
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Provided below are standard protocols that you may find useful for product applications.
May play a role in the response to environmental stress and cytokines. Appears to regulate translation by phosphorylating EIF4E, thus increasing the affinity of this protein for the 7- methylguanosine-containing mRNA cap.
Fukunaga R.,et al.EMBO J. 16:1921-1933(1997).
Knauf U.,et al.Mol. Cell. Biol. 21:5500-5511(2001).
O'Loghlen A.,et al.Exp. Cell Res. 299:343-355(2004).
Gregory S.G.,et al.Nature 441:315-321(2006).
Mural R.J.,et al.Submitted (SEP-2005) to the EMBL/GenBank/DDBJ databases.
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