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>   home   >   Products   >   Primary Antibodies   >   Cancer   >   IRF4 Antibody (C-Terminus)   

IRF4 Antibody (C-Terminus)

Rabbit Polyclonal Antibody

     
  • ICC - IRF4 Antibody (C-Terminus) ALS14824
    Immunocytochemistry of IRF4 in Jurkat cells with IRF4 antibody at 10 ug/ml.
  • IF - IRF4 Antibody (C-Terminus) ALS14824
    Immunofluorescence of IRF4 in Jurkat cells with IRF4 antibody at 20 ug/ml.
  • SPECIFICATION
  • CITATIONS
  • PROTOCOLS
  • BACKGROUND
Product Information
Application
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • E=ELISA
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
WB, IHC-P, IF, ICC
Primary Accession Q15306
Reactivity Human
Host Rabbit
Clonality Polyclonal
Calculated MW 52kDa
Dilution IHC-P (5 µg/ml), WB (1-2 µg/ml),
Additional Information
Gene ID 3662
Other Names Interferon regulatory factor 4, IRF-4, Lymphocyte-specific interferon regulatory factor, LSIRF, Multiple myeloma oncogene 1, NF-EM5, IRF4, MUM1
Target/Specificity Human IRF4. IRF4 antibody is predicted to not cross-react with other IRF protein family members. IRF4 often migrates at a higher than predicted molecular weight in SDS-PAGE.
Reconstitution & Storage Short term 4°C, long term aliquot and store at -20°C, avoid freeze thaw cycles. Store undiluted.
PrecautionsIRF4 Antibody (C-Terminus) is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Name IRF4
Synonyms MUM1
Function Transcriptional activator. Binds to the interferon- stimulated response element (ISRE) of the MHC class I promoter. Binds the immunoglobulin lambda light chain enhancer, together with PU.1. Probably plays a role in ISRE-targeted signal transduction mechanisms specific to lymphoid cells. Involved in CD8(+) dendritic cell differentiation by forming a complex with the BATF-JUNB heterodimer in immune cells, leading to recognition of AICE sequence (5'-TGAnTCA/GAAA-3'), an immune-specific regulatory element, followed by cooperative binding of BATF and IRF4 and activation of genes (By similarity).
Cellular Location Nucleus.
Tissue Location Lymphoid cells.
Research Areas
Citations (0)

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Background

Transcriptional activator. Binds to the interferon- stimulated response element (ISRE) of the MHC class I promoter. Binds the immunoglobulin lambda light chain enhancer, together with PU.1. Probably plays a role in ISRE-targeted signal transduction mechanisms specific to lymphoid cells. Involved in CD8(+) dendritic cell differentiation by forming a complex with the BATF-JUNB heterodimer in immune cells, leading to recognition of AICE sequence (5'-TGAnTCA/GAAA-3'), an immune-specific regulatory element, followed by cooperative binding of BATF and IRF4 and activation of genes (By similarity).

References

Grossman A.,et al.Genomics 37:229-233(1996).
Iida S.,et al.Nat. Genet. 17:226-230(1997).
Mungall A.J.,et al.Nature 425:805-811(2003).
Rao S.,et al.J. Biol. Chem. 274:11115-11124(1999).
Gupta S.,et al.Hum. Immunol. 64:389-401(2003).

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$ 395.00
Cat# ALS14824
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