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>   home   >   Products   >   Primary Antibodies   >   Stem Cells   >   NUMB Antibody (C-Terminus)   

NUMB Antibody (C-Terminus)

Rabbit Polyclonal Antibody

     
  • IF - NUMB Antibody (C-Terminus) ALS14826
    Immunofluorescence of NUMB in human lung tissue with NUMB antibody at 20 ug/ml.
  • WB - NUMB Antibody (C-Terminus) ALS14826
    Western blot analysis of NUMB in mouse lung tissue lysate with NUMB antibody at (A) 0.25 and (B)...
  • IHC - NUMB Antibody (C-Terminus) ALS14826
    Anti-NUMB antibody IHC of human kidney.
  • IHC - NUMB Antibody (C-Terminus) ALS14826
    Anti-NUMB antibody IHC of human uterus.
  • SPECIFICATION
  • CITATIONS
  • PROTOCOLS
  • BACKGROUND
Product Information
Application
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • E=ELISA
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
WB, IHC-P, IF
Primary Accession P49757
Reactivity Human
Host Rabbit
Clonality Polyclonal
Calculated MW 71kDa
Dilution IHC-P (5 µg/ml), WB (0.25-0.5 µg/ml),
Additional Information
Gene ID 8650
Other Names Protein numb homolog, h-Numb, Protein S171, NUMB
Target/Specificity Human NUMB. At least four isoforms of NUMB are known to exist; this antibody will detect all of them.
Reconstitution & Storage Short term 4°C, long term aliquot and store at -20°C, avoid freeze thaw cycles. Store undiluted.
PrecautionsNUMB Antibody (C-Terminus) is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Name NUMB
Function Plays a role in the process of neurogenesis. Required throughout embryonic neurogenesis to maintain neural progenitor cells, also called radial glial cells (RGCs), by allowing their daughter cells to choose progenitor over neuronal cell fate. Not required for the proliferation of neural progenitor cells before the onset of neurogenesis. Also involved postnatally in the subventricular zone (SVZ) neurogenesis by regulating SVZ neuroblasts survival and ependymal wall integrity. May also mediate local repair of brain ventricular wall damage.
Cellular Location Membrane; Peripheral membrane protein.
Research Areas
Citations (0)

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Background

Plays a role in the process of neurogenesis. Required throughout embryonic neurogenesis to maintain neural progenitor cells, also called radial glial cells (RGCs), by allowing their daughter cells to choose progenitor over neuronal cell fate. Not required for the proliferation of neural progenitor cells before the onset of neurogenesis. Also involved postnatally in the subventricular zone (SVZ) neurogenesis by regulating SVZ neuroblasts survival and ependymal wall integrity. May also mediate local repair of brain ventricular wall damage.

References

Salcini A.E.,et al.Genes Dev. 11:2239-2249(1997).
Verdi J.M.,et al.Proc. Natl. Acad. Sci. U.S.A. 96:10472-10476(1999).
Haider M.,et al.Placenta 32:441-449(2011).
Ye Q.,et al.Submitted (NOV-1998) to the EMBL/GenBank/DDBJ databases.
Ota T.,et al.Nat. Genet. 36:40-45(2004).

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$ 395.00
Cat# ALS14826
Size:
Quantity:
(40 western blots)
Availability: 5 days
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