|Application ||WB, IHC-P|
|Dilution||IHC-P (1:400), WB (1:2000),|
|Other Names||Serum paraoxonase/lactonase 3, 22.214.171.124, 126.96.36.199, 188.8.131.52, PON3|
|Reconstitution & Storage||Short term 4°C, long term aliquot and store at -20°C, avoid freeze thaw cycles.|
|Precautions||PON3 Antibody (clone 5G11) is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||Has low activity towards the organophosphate paraxon and aromatic carboxylic acid esters. Rapidly hydrolyzes lactones such as statin prodrugs (e.g. lovastatin). Hydrolyzes aromatic lactones and 5- or 6-member ring lactones with aliphatic substituents but not simple lactones or those with polar substituents.|
|Cellular Location||Secreted, extracellular space.|
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Has low activity towards the organophosphate paraxon and aromatic carboxylic acid esters. Rapidly hydrolyzes lactones such as statin prodrugs (e.g. lovastatin). Hydrolyzes aromatic lactones and 5- or 6-member ring lactones with aliphatic substituents but not simple lactones or those with polar substituents.
Reddy S.T.,et al.Submitted (NOV-2000) to the EMBL/GenBank/DDBJ databases.
Draganov D.I.,et al.Submitted (DEC-2000) to the EMBL/GenBank/DDBJ databases.
Scherer S.W.,et al.Science 300:767-772(2003).
Mural R.J.,et al.Submitted (SEP-2005) to the EMBL/GenBank/DDBJ databases.
Hillier L.W.,et al.Nature 424:157-164(2003).
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