|Application ||WB, IHC-P, ICC, IHC-Fr, Flo|
|Reactivity||Human, Mouse, Rat, Hamster, Pig, Dog, Cat|
|Dilution||Flo (1:100-1:200), IHC-Fr (1:100-1:200), IHC-P (10 µg/ml), WB (1:100-1:1000) ,|
|Other Names||Keratin, type II cytoskeletal 7, Cytokeratin-7, CK-7, Keratin-7, K7, Sarcolectin, Type-II keratin Kb7, KRT7, SCL|
|Target/Specificity||Reacts exclusively with cytokeratin 7 which is present in a subgroup of glandular epithelia and their tumors, as well as transitional epithelium and transitional carcinoma.|
|Reconstitution & Storage||Short term 4°C, long term aliquot and store at -20°C, avoid freeze thaw cycles. Store undiluted.|
|Precautions||KRT7 / CK7 / Cytokeratin 7 Antibody (clone RCK105) is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||Blocks interferon-dependent interphase and stimulates DNA synthesis in cells. Involved in the translational regulation of the human papillomavirus type 16 E7 mRNA (HPV16 E7).|
|Tissue Location||Expressed in cultured epidermal, bronchial and mesothelial cells but absent in colon, ectocervix and liver Observed throughout the glandular cells in the junction between stomach and esophagus but is absent in the esophagus|
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Provided below are standard protocols that you may find useful for product applications.
Blocks interferon-dependent interphase and stimulates DNA synthesis in cells. Involved in the translational regulation of the human papillomavirus type 16 E7 mRNA (HPV16 E7).
Glass C.,et al.J. Cell Biol. 101:2366-2373(1985).
Glass C.,et al.J. Cell Biol. 107:1337-1350(1988).
Kaba A.,et al.Biochimie 81:709-715(1999).
Smith F.J.D.,et al.Biochem. Biophys. Res. Commun. 297:818-827(2002).
Scherer S.E.,et al.Nature 440:346-351(2006).
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