|Application ||WB, IHC-P, ICC, IHC-Fr, Flo|
|Reactivity||Human, Rat, Rabbit|
|Dilution||ICC, IHC-Fr (1:100-1:200 ), IHC-P (10 µg/ml), WB (1:100-1:1000) ,|
|Other Names||Keratin, type II cytoskeletal 8, Cytokeratin-8, CK-8, Keratin-8, K8, Type-II keratin Kb8, KRT8, CYK8|
|Target/Specificity||Reacts with glandular epithelial cells (endocrine and exocrine) as well as mesothelial cells and epithelia of the digestive, respiratory and urogenital tract. Also most adenocarcinomas derived from these cells are positive. The epitope has been mappe ...|
|Reconstitution & Storage||Short term 4°C, long term aliquot and store at -20°C, avoid freeze thaw cycles. Store undiluted.|
|Precautions||KRT8 / CK8 / Cytokeratin 8 Antibody (clone M20) is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||Together with KRT19, helps to link the contractile apparatus to dystrophin at the costameres of striated muscle.|
|Cellular Location||Cytoplasm. Nucleus, nucleoplasm Nucleus matrix|
|Tissue Location||Observed in muscle fibers accumulating in the costameres of myoplasm at the sarcolemma membrane in structures that contain dystrophin and spectrin. Expressed in gingival mucosa and hard palate of the oral cavity.|
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Provided below are standard protocols that you may find useful for product applications.
Together with KRT19, helps to link the contractile apparatus to dystrophin at the costameres of striated muscle.
Krauss S.,et al.Gene 86:241-249(1990).
Yamamoto R.,et al.Mol. Endocrinol. 4:370-374(1990).
Waseem A.,et al.New Biol. 2:464-478(1990).
Ku N.-O.,et al.J. Biol. Chem. 272:7556-7564(1997).
Ota T.,et al.Nat. Genet. 36:40-45(2004).
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