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NF-L / NEFL Antibody (clone 2F11)
Mouse Monoclonal Antibody
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Application 
| WB, IHC-P, IHC-Fr |
|---|---|
| Primary Accession | P07196 |
| Reactivity | Human, Opossum |
| Host | Mouse |
| Clonality | Monoclonal |
| Clone Names | 2F11 |
| Calculated MW | 62kDa |
| Dilution | IHC-Fr (1:25-1:200), IHC-P (10 µg/ml), WB (1:100-1:1000) |
| Gene ID | 4747 |
|---|---|
| Other Names | Neurofilament light polypeptide, NF-L, 68 kDa neurofilament protein, Neurofilament triplet L protein, NEFL, NF68, NFL |
| Target/Specificity | Reacts exclusively with the phosphorylated isoform of the70 kD neurofilament protein. |
| Reconstitution & Storage | Short term 4°C, long term aliquot and store at -20°C, avoid freeze thaw cycles. Store undiluted. |
| Precautions | NF-L / NEFL Antibody (clone 2F11) is for research use only and not for use in diagnostic or therapeutic procedures. |
| Name | NEFL |
|---|---|
| Synonyms | NF68, NFL |
| Function | Neurofilaments usually contain three intermediate filament proteins: NEFL, NEFM, and NEFH which are involved in the maintenance of neuronal caliber. May additionally cooperate with the neuronal intermediate filament proteins PRPH and INA to form neuronal filamentous networks (By similarity). |
| Cellular Location | Cell projection, axon {ECO:0000250|UniProtKB:P08551}. Cytoplasm, cytoskeleton {ECO:0000250|UniProtKB:P08551} |
Thousands of laboratories across the world have published research that depended on the performance of antibodies from Abcepta to advance their research. Check out links to articles that cite our products in major peer-reviewed journals, organized by research category.
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Provided below are standard protocols that you may find useful for product applications.
Background
Neurofilaments usually contain three intermediate filament proteins: L, M, and H which are involved in the maintenance of neuronal caliber.
References
Julien J.-P.,et al.Biochim. Biophys. Acta 909:10-20(1987).
Perez-Olle R.,et al.J. Cell Sci. 115:4937-4946(2002).
Nusbaum C.,et al.Nature 439:331-335(2006).
Mural R.J.,et al.Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases.
Pospelov V.A.,et al.Cell Growth Differ. 5:187-196(1994).
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