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NEFH / NF-H Antibody (clone RNF402)
Mouse Monoclonal Antibody
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Application 
| WB, IHC-P, IHC-Fr |
|---|---|
| Primary Accession | P12036 |
| Reactivity | Human, Mouse, Rat, Rabbit, Hamster, Monkey, Chicken, Sheep, Xenopus, Bovine, Guinea Pig, Dog |
| Host | Mouse |
| Clonality | Monoclonal |
| Clone Names | RNF402 |
| Calculated MW | 112kDa |
| Dilution | IHC-Fr (1:10-1:100), IHC-P (10 µg/ml), WB (1:25-1:250) |
| Gene ID | 4744 |
|---|---|
| Other Names | Neurofilament heavy polypeptide, NF-H, 200 kDa neurofilament protein, Neurofilament triplet H protein, NEFH, KIAA0845, NFH |
| Target/Specificity | Reacts with both the phosphorylated and non-phosphorylated isoform of the 200 kD neurofilament protein. |
| Reconstitution & Storage | Short term 4°C, long term aliquot and store at -20°C, avoid freeze thaw cycles. Store undiluted. |
| Precautions | NEFH / NF-H Antibody (clone RNF402) is for research use only and not for use in diagnostic or therapeutic procedures. |
| Name | NEFH |
|---|---|
| Synonyms | KIAA0845, NFH |
| Function | Neurofilaments usually contain three intermediate filament proteins: NEFL, NEFM, and NEFH which are involved in the maintenance of neuronal caliber. NEFH has an important function in mature axons that is not subserved by the two smaller NF proteins. May additionally cooperate with the neuronal intermediate filament proteins PRPH and INA to form neuronal filamentous networks (By similarity). |
| Cellular Location | Cytoplasm, cytoskeleton. Cell projection, axon {ECO:0000250|UniProtKB:P19246} |
Thousands of laboratories across the world have published research that depended on the performance of antibodies from Abcepta to advance their research. Check out links to articles that cite our products in major peer-reviewed journals, organized by research category.
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Provided below are standard protocols that you may find useful for product applications.
Background
Neurofilaments usually contain three intermediate filament proteins: L, M, and H which are involved in the maintenance of neuronal caliber. NF-H has an important function in mature axons that is not subserved by the two smaller NF proteins.
References
Lees J.F.,et al.EMBO J. 7:1947-1955(1988).
Zhu Y.,et al.Beijing Yi Ke Da Xue Xue Bao 31:531-531(1999).
Nagase T.,et al.DNA Res. 5:355-364(1998).
Ota T.,et al.Nat. Genet. 36:40-45(2004).
Dunham I.,et al.Nature 402:489-495(1999).
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