|Application ||WB, IHC-P, ICC, IP, IHC-Fr|
|Reactivity||Human, Mouse, Dog|
|Dilution||IHC-Fr (1:25-1:200), IHC-P (20 µg/ml), WB (1:100-1:1000)|
|Other Names||Plakophilin-3, PKP3|
|Target/Specificity||Reacts with an epitope located between residues 570-589 in human plakophilin-3.|
|Reconstitution & Storage||Short term 4°C, long term aliquot and store at -20°C, avoid freeze thaw cycles. Store undiluted.|
|Precautions||PKP3 / Plakophilin 3 Antibody (clone 23E3/4) is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||May play a role in junctional plaques.|
|Cellular Location||Nucleus. Cell junction, desmosome. Note=Nuclear and associated with desmosomes|
|Tissue Location||Isoform PKP3a is found in desmosomes of most simple and stratified epithelia. Not found in foreskin fibroblasts and various sarcoma-derived cell lines. Beside dendritic reticular cells of lymphatic follicles not found in non-epithelial desmosome-bearing tissues. Isoform PKP3b is abundant in the desmosomes of stratified epithelial cell but absent in simple epithelial cells, it is also expressed in the colon and its tumors.|
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Provided below are standard protocols that you may find useful for product applications.
May play a role in junctional plaques.
Schmidt A.,et al.Differentiation 64:291-306(1999).
Bonne S.,et al.J. Cell Sci. 112:2265-2276(1999).
Muhmer M.,et al.Cell Tissue Res. 355:143-162(2014).
Totoki Y.,et al.Submitted (APR-2005) to the EMBL/GenBank/DDBJ databases.
Kimura K.,et al.Genome Res. 16:55-65(2006).
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