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>   home   >   Products   >   Primary Antibodies   >   Immunology   >   EBI3 Antibody (aa120-170)   

EBI3 Antibody (aa120-170)

Rabbit Polyclonal Antibody

     
  • IHC - EBI3 Antibody (aa120-170) ALS14886
    Anti-EBI3 antibody IHC of human placenta.
  • WB - EBI3 Antibody (aa120-170) ALS14886
    Western blot of EBI3 in Jurkat cell lysate in the 1) absence and 2) presence of immunizing...
  • SPECIFICATION
  • CITATIONS
  • PROTOCOLS
  • BACKGROUND
Product Information
Application
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • E=ELISA
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
WB, IHC-P
Primary Accession Q14213
Reactivity Human
Host Rabbit
Clonality Polyclonal
Calculated MW 25kDa
Dilution IHC-P (1:100), WB (2-5 µg/ml),
Additional Information
Gene ID 10148
Other Names Interleukin-27 subunit beta, IL-27 subunit beta, IL-27B, Epstein-Barr virus-induced gene 3 protein, EBV-induced gene 3 protein, EBI3, IL27B
Target/Specificity Human EBI3
Reconstitution & Storage Store at 4°C, stable for 6 months. For long term storage, aliquot and store at -20°C.
PrecautionsEBI3 Antibody (aa120-170) is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Name EBI3
Synonyms IL27B
Function Associates with IL27 to form the IL-27 interleukin, a heterodimeric cytokine which functions in innate immunity. IL-27 has pro- and anti-inflammatory properties, that can regulate T- helper cell development, suppress T-cell proliferation, stimulate cytotoxic T-cell activity, induce isotype switching in B-cells, and that has diverse effects on innate immune cells. Among its target cells are CD4 T-helper cells which can differentiate in type 1 effector cells (TH1), type 2 effector cells (TH2) and IL17 producing helper T-cells (TH17). It drives rapid clonal expansion of naive but not memory CD4 T-cells. It also strongly synergizes with IL-12 to trigger interferon-gamma/IFN-gamma production of naive CD4 T-cells, binds to the cytokine receptor WSX-1/TCCR. Another important role of IL-27 is its antitumor activity as well as its antiangiogenic activity with activation of production of antiangiogenic chemokines.
Cellular Location Secreted.
Volume 50 µl
Research Areas
Citations (0)

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Background

Associates with IL27 to form the IL-27 interleukin, a heterodimeric cytokine which functions in innate immunity. IL-27 has pro- and anti-inflammatory properties, that can regulate T- helper cell development, suppress T-cell proliferation, stimulate cytotoxic T-cell activity, induce isotype switching in B-cells, and that has diverse effects on innate immune cells. Among its target cells are CD4 T-helper cells which can differentiate in type 1 effector cells (TH1), type 2 effector cells (TH2) and IL17 producing helper T-cells (TH17). It drives rapid clonal expansion of naive but not memory CD4 T-cells. It also strongly synergizes with IL-12 to trigger interferon-gamma/IFN-gamma production of naive CD4 T-cells, binds to the cytokine receptor WSX-1/TCCR. Another important role of IL-27 is its antitumor activity as well as its antiangiogenic activity with activation of production of antiangiogenic chemokines.

References

Devergne O.,et al.J. Virol. 70:1143-1153(1996).
Livingston R.J.,et al.Submitted (OCT-2006) to the EMBL/GenBank/DDBJ databases.
Grimwood J.,et al.Nature 428:529-535(2004).
Mural R.J.,et al.Submitted (SEP-2005) to the EMBL/GenBank/DDBJ databases.
Devergne O.,et al.Proc. Natl. Acad. Sci. U.S.A. 94:12041-12046(1997).

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$ 395.00
Cat# ALS14886
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