|Application ||WB, IHC-P|
|Dilution||IHC-P (10 µg/ml), WB (0.5-2 µg/ml),|
|Other Names||Regulator of G-protein signaling 19, RGS19, G-alpha-interacting protein, GAIP, RGS19, GAIP, GNAI3IP|
|Reconstitution & Storage||Store at 4°C, stable for 6 months. For long term storage, aliquot and store at -20°C.|
|Precautions||RGS19 Antibody (aa1-50) is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||Inhibits signal transduction by increasing the GTPase activity of G protein alpha subunits thereby driving them into their inactive GDP-bound form. Binds to G-alpha subfamily 1 members, with the order G(i)a3 > G(i)a1 > G(o)a >> G(z)a/G(i)a2. Activity on G(z)-alpha is inhibited by phosphorylation and palmitoylation of the G-protein.|
|Cellular Location||Membrane; Lipid-anchor.|
|Tissue Location||Highest expression in lung. Placenta, liver and heart also express high levels of GAIP|
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Inhibits signal transduction by increasing the GTPase activity of G protein alpha subunits thereby driving them into their inactive GDP-bound form. Binds to G-alpha subfamily 1 members, with the order G(i)a3 > G(i)a1 > G(o)a >> G(z)a/G(i)a2. Activity on G(z)-alpha is inhibited by phosphorylation and palmitoylation of the G-protein.
de Vries L.,et al.Proc. Natl. Acad. Sci. U.S.A. 92:11916-11920(1995).
Puhl H.L. III,et al.Submitted (MAR-2004) to the EMBL/GenBank/DDBJ databases.
Kalnine N.,et al.Submitted (AUG-2003) to the EMBL/GenBank/DDBJ databases.
Ota T.,et al.Nat. Genet. 36:40-45(2004).
Deloukas P.,et al.Nature 414:865-871(2001).
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