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HFE2 / Hemojuvelin Antibody (clone 1C12)

Mouse Monoclonal Antibody

     
  • IHC - HFE2 / Hemojuvelin Antibody (clone 1C12) ALS14895
    Anti-HFE2 antibody IHC of human small intestine.
  • SPECIFICATION
  • CITATIONS
  • PROTOCOLS
  • BACKGROUND
Product Information
Application
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • E=ELISA
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
WB, IHC-P, E
Primary Accession Q6ZVN8
Reactivity Human
Host Mouse
Clonality Monoclonal
Clone Names 1C12
Calculated MW 45kDa
Dilution IHC-P (5 µg/ml)
Additional Information
Gene ID 148738
Other Names Hemojuvelin, Hemochromatosis type 2 protein, RGM domain family member C, HFE2, HJV, RGMC
Target/Specificity Human HFE2
Reconstitution & Storage Short term 4°C, long term aliquot and store at -20°C, avoid freeze thaw cycles.
PrecautionsHFE2 / Hemojuvelin Antibody (clone 1C12) is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Name HFE2
Synonyms HJV, RGMC
Function Acts as a bone morphogenetic protein (BMP) coreceptor. Through enhancement of BMP signaling regulates hepcidin (HAMP) expression and regulates iron homeostasis.
Cellular Location Cell membrane; Lipid-anchor, GPI-anchor. Note=Also released in the extracellular space.
Tissue Location Adult and fetal liver, heart, and skeletal muscle.
Research Areas
Citations (0)

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Background

Member of the repulsive guidance molecule (RGM) family. Involved in iron metabolism. Acts as a bone morphogenetic protein (BMP) coreceptor (By similarity). Enhancement of BMP signaling regulates hepcidin (HAMP) expression and iron metabolism (By similarity). May cooperate with hepcidin to restrict iron absorption in the gut. Could represent the cellular receptor for hepcidin.

References

Papanikolaou G.,et al.Nat. Genet. 36:77-82(2004).
Ota T.,et al.Nat. Genet. 36:40-45(2004).
Gregory S.G.,et al.Nature 441:315-321(2006).
Mural R.J.,et al.Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases.
Babitt J.L.,et al.Nat. Genet. 38:531-539(2006).

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$ 450.00
Cat# ALS14895
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