|Application ||WB, IHC-P, E|
|Dilution||IHC-P (5 µg/ml)|
|Other Names||Hemojuvelin, Hemochromatosis type 2 protein, RGM domain family member C, HFE2, HJV, RGMC|
|Reconstitution & Storage||Short term 4°C, long term aliquot and store at -20°C, avoid freeze thaw cycles.|
|Precautions||HFE2 / Hemojuvelin Antibody (clone 1C12) is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||Acts as a bone morphogenetic protein (BMP) coreceptor. Through enhancement of BMP signaling regulates hepcidin (HAMP) expression and regulates iron homeostasis.|
|Cellular Location||Cell membrane; Lipid-anchor, GPI-anchor. Note=Also released in the extracellular space.|
|Tissue Location||Adult and fetal liver, heart, and skeletal muscle.|
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Provided below are standard protocols that you may find useful for product applications.
Member of the repulsive guidance molecule (RGM) family. Involved in iron metabolism. Acts as a bone morphogenetic protein (BMP) coreceptor (By similarity). Enhancement of BMP signaling regulates hepcidin (HAMP) expression and iron metabolism (By similarity). May cooperate with hepcidin to restrict iron absorption in the gut. Could represent the cellular receptor for hepcidin.
Papanikolaou G.,et al.Nat. Genet. 36:77-82(2004).
Ota T.,et al.Nat. Genet. 36:40-45(2004).
Gregory S.G.,et al.Nature 441:315-321(2006).
Mural R.J.,et al.Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases.
Babitt J.L.,et al.Nat. Genet. 38:531-539(2006).
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