TOMM22 / TOM22 Antibody (clone 4G4)
Mouse Monoclonal Antibody
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Application
| WB, IHC-P, IF, E |
---|---|
Primary Accession | Q9NS69 |
Reactivity | Human, Mouse, Rat |
Host | Mouse |
Clonality | Monoclonal |
Clone Names | 4G4 |
Calculated MW | 16kDa |
Dilution | IF (10 µg/ml), IHC-P (10 µg/ml), |
Gene ID | 56993 |
---|---|
Other Names | Mitochondrial import receptor subunit TOM22 homolog, hTom22, 1C9-2, Translocase of outer membrane 22 kDa subunit homolog, TOMM22, TOM22 |
Target/Specificity | Human TOMM22 |
Reconstitution & Storage | Short term 4°C, long term aliquot and store at -20°C, avoid freeze thaw cycles. |
Precautions | TOMM22 / TOM22 Antibody (clone 4G4) is for research use only and not for use in diagnostic or therapeutic procedures. |
Name | TOMM22 |
---|---|
Synonyms | TOM22 |
Function | Central receptor component of the translocase of the outer membrane of mitochondria (TOM complex) responsible for the recognition and translocation of cytosolically synthesized mitochondrial preproteins. Together with the peripheral receptor TOM20 functions as the transit peptide receptor and facilitates the movement of preproteins into the translocation pore (PubMed:10982837). Required for the translocation across the mitochondrial outer membrane of cytochrome P450 monooxygenases (By similarity). |
Cellular Location | Mitochondrion outer membrane; Single-pass membrane protein |
Tissue Location | Ubiquitous. |
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Provided below are standard protocols that you may find useful for product applications.
Background
Central receptor component of the translocase of the outer membrane of mitochondria (TOM complex) responsible for the recognition and translocation of cytosolically synthesized mitochondrial preproteins. Together with the peripheral receptor TOM20 functions as the transit peptide receptor and facilitates the movement of preproteins into the translocation pore.
References
Yano M.,et al.Mol. Cell. Biol. 20:7205-7213(2000).
Saeki K.,et al.J. Biol. Chem. 275:31996-32002(2000).
Ota T.,et al.Nat. Genet. 36:40-45(2004).
Collins J.E.,et al.Genome Biol. 5:R84.1-R84.11(2004).
Bienvenut W.V.,et al.Submitted (JUN-2005) to UniProtKB.
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