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DDX4 / VASA Antibody (aa700-724)

Rabbit Polyclonal Antibody

     
  • IHC - DDX4 / VASA Antibody (aa700-724) ALS14900
    Anti-DDX4 antibody IHC of human testis.
  • SPECIFICATION
  • CITATIONS
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Product Information
Application
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • E=ELISA
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
IHC-P
Primary Accession Q9NQI0
Reactivity Human, Mouse, Monkey, Horse, Dog
Host Rabbit
Clonality Polyclonal
Calculated MW 79kDa
Dilution IHC-P (5 µg/ml)
Additional Information
Gene ID 54514
Other Names Probable ATP-dependent RNA helicase DDX4, 3.6.4.13, DEAD box protein 4, Vasa homolog, DDX4, VASA
Target/Specificity Human DDX4
Reconstitution & Storage Store at 4°C for short term applications. For long term storage, aliquot and store at -20°C.
PrecautionsDDX4 / VASA Antibody (aa700-724) is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Name DDX4
Synonyms VASA
Function Probable ATP-dependent RNA helicase required during spermatogenesis (PubMed:10920202, PubMed:21034600). Required to repress transposable elements and preventing their mobilization, which is essential for the germline integrity. Acts via the piRNA metabolic process, which mediates the repression of transposable elements during meiosis by forming complexes composed of piRNAs and Piwi proteins and governs the methylation and subsequent repression of transposons. Involved in the secondary piRNAs metabolic process, the production of piRNAs in fetal male germ cells through a ping-pong amplification cycle (By similarity).
Cellular Location Cytoplasm {ECO:0000250|UniProtKB:Q61496}. Cytoplasm, perinuclear region {ECO:0000250|UniProtKB:Q61496} Note=Component of the meiotic nuage, also named P granule, a germ- cell-specific organelle required to repress transposon activity during meiosis. {ECO:0000250|UniProtKB:Q61496}
Tissue Location Expressed only in ovary and testis. Expressed in migratory primordial germ cells in the region of the gonadal ridge in both sexes.
Research Areas
Citations (0)

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Background

May play a role in germ cell development. May play a role in sperm motility.

References

Castrillon D.H.,et al.Proc. Natl. Acad. Sci. U.S.A. 97:9585-9590(2000).
Rocha D.,et al.Submitted (MAY-2000) to the EMBL/GenBank/DDBJ databases.
Ota T.,et al.Nat. Genet. 36:40-45(2004).
Schmutz J.,et al.Nature 431:268-274(2004).
Mural R.J.,et al.Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases.

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$ 395.00
Cat# ALS14900
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