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GLI / GLI1 Antibody (aa940-990)
Rabbit Polyclonal Antibody
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Application 
| WB, IHC-P |
|---|---|
| Primary Accession | P08151 |
| Reactivity | Human, Monkey |
| Host | Rabbit |
| Clonality | Polyclonal |
| Calculated MW | 118kDa |
| Dilution | IHC-P (5-10 µg/ml), WB (1-3 µg/ml), |
| Gene ID | 2735 |
|---|---|
| Other Names | Zinc finger protein GLI1, Glioma-associated oncogene, Oncogene GLI, GLI1, GLI |
| Target/Specificity | Human GLI1 |
| Reconstitution & Storage | Store at 4°C for short term applications. For long term storage, aliquot and store at -20°C. |
| Precautions | GLI / GLI1 Antibody (aa940-990) is for research use only and not for use in diagnostic or therapeutic procedures. |
| Name | GLI1 |
|---|---|
| Synonyms | GLI |
| Function | Acts as a transcriptional activator (PubMed:19706761, PubMed:10806483, PubMed:19878745, PubMed:24076122, PubMed:24311597, PubMed:24217340). Binds to the DNA consensus sequence 5'-GACCACCCA-3' (PubMed:2105456, PubMed:8378770, PubMed:24217340). Regulates the transcription of specific genes during normal development (PubMed:19706761). Plays a role in craniofacial development and digital development, as well as development of the central nervous system and gastrointestinal tract. Mediates SHH signaling (PubMed:19706761, PubMed:28973407). Plays a role in cell proliferation and differentiation via its role in SHH signaling (PubMed:11238441, PubMed:28973407). |
| Cellular Location | Cytoplasm. Nucleus. Note=Tethered in the cytoplasm by binding to SUFU (PubMed:10806483). Activation and translocation to the nucleus is promoted by interaction with STK36 (PubMed:10806483). Phosphorylation by ULK3 may promote nuclear localization (PubMed:19878745). Translocation to the nucleus is promoted by interaction with ZIC1 (PubMed:11238441) |
| Tissue Location | Detected in testis (at protein level) (PubMed:2105456). Testis, myometrium and fallopian tube. Also expressed in the brain with highest expression in the cerebellum, optic nerve and olfactory tract (PubMed:19878745). Isoform 1 is detected in brain, spleen, pancreas, liver, kidney and placenta; isoform 2 is not detectable in these tissues (PubMed:19706761) |
Thousands of laboratories across the world have published research that depended on the performance of antibodies from Abcepta to advance their research. Check out links to articles that cite our products in major peer-reviewed journals, organized by research category.
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Provided below are standard protocols that you may find useful for product applications.
Background
Acts as a transcriptional activator. May regulate the transcription of specific genes during normal development. May play a role in craniofacial development and digital development, as well as development of the central nervous system and gastrointestinal tract. Mediates SHH signaling and thus cell proliferation and differentiation.
References
Kinzler K.W.,et al.Nature 332:371-374(1988).
Yoon J.W.,et al.Submitted (OCT-2000) to the EMBL/GenBank/DDBJ databases.
Lo H.W.,et al.Cancer Res. 69:6790-6798(2009).
Scherer S.E.,et al.Nature 440:346-351(2006).
Murone M.,et al.Nat. Cell Biol. 2:310-312(2000).
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