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GLI / GLI1 Antibody (aa940-990)

Rabbit Polyclonal Antibody

     
  • WB - GLI / GLI1 Antibody (aa940-990) ALS14910
    Western blot of GLI1 in human kidney lysate using 1) pre-immune sera at 1:5000 dilution and 2)...
  • SPECIFICATION
  • CITATIONS
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Product Information
Application
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • E=ELISA
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
WB, IHC-P
Primary Accession P08151
Reactivity Human, Monkey
Host Rabbit
Clonality Polyclonal
Calculated MW 118kDa
Dilution IHC-P (5-10 µg/ml), WB (1-3 µg/ml),
Additional Information
Gene ID 2735
Other Names Zinc finger protein GLI1, Glioma-associated oncogene, Oncogene GLI, GLI1, GLI
Target/Specificity Human GLI1
Reconstitution & Storage Store at 4°C for short term applications. For long term storage, aliquot and store at -20°C.
PrecautionsGLI / GLI1 Antibody (aa940-990) is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Name GLI1
Synonyms GLI
Function Acts as a transcriptional activator. May regulate the transcription of specific genes during normal development. May play a role in craniofacial development and digital development, as well as development of the central nervous system and gastrointestinal tract. Mediates SHH signaling and thus cell proliferation and differentiation.
Cellular Location Cytoplasm. Nucleus. Note=Tethered in the cytoplasm by binding to SUFU. Activation and translocation to the nucleus is promoted by interaction with STK36. Phosphorylation by ULK3 may promote nuclear localization. Translocation to the nucleus is promoted by interaction with ZIC1
Tissue Location Testis, myometrium and fallopian tube. Also expressed in the brain with highest expression in the cerebellum, optic nerve and olfactory tract.
Research Areas
Citations (0)

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Background

Acts as a transcriptional activator. May regulate the transcription of specific genes during normal development. May play a role in craniofacial development and digital development, as well as development of the central nervous system and gastrointestinal tract. Mediates SHH signaling and thus cell proliferation and differentiation.

References

Kinzler K.W.,et al.Nature 332:371-374(1988).
Yoon J.W.,et al.Submitted (OCT-2000) to the EMBL/GenBank/DDBJ databases.
Lo H.W.,et al.Cancer Res. 69:6790-6798(2009).
Scherer S.E.,et al.Nature 440:346-351(2006).
Murone M.,et al.Nat. Cell Biol. 2:310-312(2000).

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$ 395.00
Cat# ALS14910
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