|Application ||WB, IHC-P, E|
|Reactivity||Human, Mouse, Rat, Rabbit, Pig, Goat, Bovine, Fish, Dog, Cat|
|Dilution||IHC-P (10 µg/ml)|
|Other Names||Troponin C, slow skeletal and cardiac muscles, TN-C, TNNC1, TNNC|
|Target/Specificity||Recognizes cardiac and skeletal troponin I. It is specific for an epitope between aa186-192 of cardiac troponin I. Species cross-reactivity: Mouse, Cat, Rabbit, Dog, Pig, Rat, Goat, Bovine, Fish.|
|Reconstitution & Storage||May be stored at 4°C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20°C. Aliquots are stable for at least 12 months.|
|Precautions||TNNC1 / Cardiac Troponin C Antibody is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||Troponin is the central regulatory protein of striated muscle contraction. Tn consists of three components: Tn-I which is the inhibitor of actomyosin ATPase, Tn-T which contains the binding site for tropomyosin and Tn-C. The binding of calcium to Tn-C abolishes the inhibitory action of Tn on actin filaments.|
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Provided below are standard protocols that you may find useful for product applications.
Troponin is the central regulatory protein of striated muscle contraction. Tn consists of three components: Tn-I which is the inhibitor of actomyosin ATPase, Tn-T which contains the binding site for tropomyosin and Tn-C. The binding of calcium to Tn-C abolishes the inhibitory action of Tn on actin filaments.
Roher A.,et al.Muscle Nerve 9:73-77(1986).
Gahlmann R.,et al.J. Mol. Biol. 201:379-391(1988).
Schreier T.,et al.J. Biol. Chem. 265:21247-21253(1990).
Margossian S.S.,et al.Submitted (AUG-1997) to the EMBL/GenBank/DDBJ databases.
Spyracopoulos L.,et al.Biochemistry 36:12138-12146(1997).
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