ABCA1 Antibody
Rabbit Polyclonal Antibody
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Application
| WB, IHC-P |
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Primary Accession | O95477 |
Reactivity | Human, Mouse |
Host | Rabbit |
Clonality | Polyclonal |
Calculated MW | 254kDa |
Dilution | IHC-P (1:100), WB (1:500-1:5000), |
Gene ID | 19 |
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Other Names | ATP-binding cassette sub-family A member 1, ATP-binding cassette transporter 1, ABC-1, ATP-binding cassette 1, Cholesterol efflux regulatory protein, ABCA1, ABC1, CERP |
Target/Specificity | This Polyclonal antibody is directed against human ABCA1 protein. The product was purified from serum by protein A chromatography. Expect reactivity with human ABCA1. Cross-reactivity with ABCA1 from other sources has not been determined. |
Reconstitution & Storage | Short term 4°C, long term aliquot and store at -20°C, avoid freeze thaw cycles. |
Precautions | ABCA1 Antibody is for research use only and not for use in diagnostic or therapeutic procedures. |
Name | ABCA1 (HGNC:29) |
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Synonyms | ABC1, CERP |
Function | Catalyzes the translocation of specific phospholipids from the cytoplasmic to the extracellular/lumenal leaflet of membrane coupled to the hydrolysis of ATP (PubMed:24097981, PubMed:35974019). Thereby, participates in phospholipid transfer to apolipoproteins to form nascent high density lipoproteins/HDLs (PubMed:14754908). Transports preferentially phosphatidylcholine over phosphatidylserine (PubMed:24097981). May play a similar role in the efflux of intracellular cholesterol to apolipoproteins and the formation of nascent high density lipoproteins/HDLs (PubMed:10533863, PubMed:14754908, PubMed:24097981, PubMed:35974019). Translocates phospholipids from the outer face of the plasma membrane and forces it through its gateway and annulus into an elongated hydrophobic tunnel in its extracellular domain (PubMed:35974019). |
Cellular Location | Cell membrane; Multi-pass membrane protein. Endosome |
Tissue Location | Widely expressed, but most abundant in macrophages. |
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Provided below are standard protocols that you may find useful for product applications.
Background
cAMP-dependent and sulfonylurea-sensitive anion transporter. Key gatekeeper influencing intracellular cholesterol transport.
References
Santamarina-Fojo S.,et al.Proc. Natl. Acad. Sci. U.S.A. 97:7987-7992(2000).
Schwartz K.,et al.Submitted (JUL-2000) to the EMBL/GenBank/DDBJ databases.
Qiu Y.,et al.Genomics 73:66-76(2001).
Tanaka A.R.,et al.Submitted (FEB-2001) to the EMBL/GenBank/DDBJ databases.
Humphray S.J.,et al.Nature 429:369-374(2004).
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