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ABCA1 Antibody

Rabbit Polyclonal Antibody

     
  • IHC - ABCA1 Antibody ALS14938
    Anti-ABCA1 antibody IHC of human liver.
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Product Information
Application
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • E=ELISA
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
WB, IHC-P
Primary Accession O95477
Reactivity Human, Mouse
Host Rabbit
Clonality Polyclonal
Calculated MW 254kDa
Dilution IHC-P (1:100), WB (1:500-1:5000),
Additional Information
Gene ID 19
Other Names ATP-binding cassette sub-family A member 1, ATP-binding cassette transporter 1, ABC-1, ATP-binding cassette 1, Cholesterol efflux regulatory protein, ABCA1, ABC1, CERP
Target/Specificity This Polyclonal antibody is directed against human ABCA1 protein. The product was purified from serum by protein A chromatography. Expect reactivity with human ABCA1. Cross-reactivity with ABCA1 from other sources has not been determined.
Reconstitution & Storage Short term 4°C, long term aliquot and store at -20°C, avoid freeze thaw cycles.
PrecautionsABCA1 Antibody is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Name ABCA1 (HGNC:29)
Synonyms ABC1, CERP
Function Catalyzes the translocation of specific phospholipids from the cytoplasmic to the extracellular/lumenal leaflet of membrane coupled to the hydrolysis of ATP (PubMed:24097981, PubMed:35974019). Thereby, participates in phospholipid transfer to apolipoproteins to form nascent high density lipoproteins/HDLs (PubMed:14754908). Transports preferentially phosphatidylcholine over phosphatidylserine (PubMed:24097981). May play a similar role in the efflux of intracellular cholesterol to apolipoproteins and the formation of nascent high density lipoproteins/HDLs (PubMed:10533863, PubMed:14754908, PubMed:24097981, PubMed:35974019). Translocates phospholipids from the outer face of the plasma membrane and forces it through its gateway and annulus into an elongated hydrophobic tunnel in its extracellular domain (PubMed:35974019).
Cellular Location Cell membrane; Multi-pass membrane protein. Endosome
Tissue Location Widely expressed, but most abundant in macrophages.
Research Areas
Citations (0)
citation

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Background

cAMP-dependent and sulfonylurea-sensitive anion transporter. Key gatekeeper influencing intracellular cholesterol transport.

References

Santamarina-Fojo S.,et al.Proc. Natl. Acad. Sci. U.S.A. 97:7987-7992(2000).
Schwartz K.,et al.Submitted (JUL-2000) to the EMBL/GenBank/DDBJ databases.
Qiu Y.,et al.Genomics 73:66-76(2001).
Tanaka A.R.,et al.Submitted (FEB-2001) to the EMBL/GenBank/DDBJ databases.
Humphray S.J.,et al.Nature 429:369-374(2004).

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$ 467.50
Cat# ALS14938
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