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VLDLR Antibody (clone 1H10)

Mouse Monoclonal Antibody

     
  • IHC - VLDLR Antibody (clone 1H10) ALS14939
    Anti-VLDLR antibody IHC of human brain, cerebellum, Purkinje.
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  • SPECIFICATION
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Product Information
Application
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • E=ELISA
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
WB, IHC-P, E
Primary Accession P98155
Reactivity Human
Host Mouse
Clonality Monoclonal
Clone Names 1H10
Calculated MW 96kDa
Dilution IHC-P (1:50)
Additional Information
Gene ID 7436
Other Names Very low-density lipoprotein receptor, VLDL receptor, VLDL-R, VLDLR
Target/Specificity Binds to an epitope on the C-terminus of the ligand binding domain (aa191-355) of VLDL receptor and blocks apoE4 binding.
Reconstitution & Storage Long term: -70°C; Short term: -70°C
PrecautionsVLDLR Antibody (clone 1H10) is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Name VLDLR
Function Multifunctional cell surface receptor that binds VLDL and transports it into cells by endocytosis and therefore plays an important role in energy metabolism. Binds also to a wide range of other molecules including Reelin/RELN or apolipoprotein E/APOE- containing ligands as well as clusterin/CLU (PubMed:24381170, PubMed:30873003). In the off-state of the pathway, forms homooligomers or heterooligomers with LRP8 (PubMed:30873003). Upon binding to ligands, homooligomers are rearranged to higher order receptor clusters that transmit the extracellular RELN signal to intracellular signaling processes by binding to DAB1 (PubMed:30873003). This interaction results in phosphorylation of DAB1 leading to the ultimate cell responses required for the correct positioning of newly generated neurons. Later, mediates a stop signal for migrating neurons, preventing them from entering the marginal zone (By similarity).
Cellular Location Cell membrane; Single-pass type I membrane protein Membrane, clathrin-coated pit; Single-pass type I membrane protein
Tissue Location Abundant in heart and skeletal muscle; also ovary and kidney; not in liver
Research Areas
Citations (0)
citation

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Background

Binds VLDL and transports it into cells by endocytosis. In order to be internalized, the receptor-ligand complexes must first cluster into clathrin-coated pits. Binding to Reelin induces tyrosine phosphorylation of Dab1 and modulation of Tau phosphorylation (By similarity).

References

Gafvels M.E.,et al.Somat. Cell Mol. Genet. 19:557-569(1993).
Webb J.C.,et al.Hum. Mol. Genet. 3:531-537(1994).
Sakai J.,et al.J. Biol. Chem. 269:2173-2182(1994).
Oka K.,et al.Genomics 20:298-300(1994).
Humphray S.J.,et al.Nature 429:369-374(2004).

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$ 467.50
Cat# ALS14939
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