|Application ||WB, IHC-P, E|
|Other Names||Very low-density lipoprotein receptor, VLDL receptor, VLDL-R, VLDLR|
|Target/Specificity||Binds to an epitope on the C-terminus of the ligand binding domain (aa191-355) of VLDL receptor and blocks apoE4 binding.|
|Reconstitution & Storage||Long term: -70°C; Short term: -70°C|
|Precautions||VLDLR Antibody (clone 1H10) is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||Binds VLDL and transports it into cells by endocytosis. In order to be internalized, the receptor-ligand complexes must first cluster into clathrin-coated pits. Binding to Reelin induces tyrosine phosphorylation of Dab1 and modulation of Tau phosphorylation (By similarity).|
|Cellular Location||Membrane; Single-pass type I membrane protein. Membrane, clathrin-coated pit; Single-pass type I membrane protein|
|Tissue Location||Abundant in heart and skeletal muscle; also ovary and kidney; not in liver|
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Provided below are standard protocols that you may find useful for product applications.
Binds VLDL and transports it into cells by endocytosis. In order to be internalized, the receptor-ligand complexes must first cluster into clathrin-coated pits. Binding to Reelin induces tyrosine phosphorylation of Dab1 and modulation of Tau phosphorylation (By similarity).
Gafvels M.E.,et al.Somat. Cell Mol. Genet. 19:557-569(1993).
Webb J.C.,et al.Hum. Mol. Genet. 3:531-537(1994).
Sakai J.,et al.J. Biol. Chem. 269:2173-2182(1994).
Oka K.,et al.Genomics 20:298-300(1994).
Humphray S.J.,et al.Nature 429:369-374(2004).
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