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>   home   >   Products   >   Primary Antibodies   >   Signal Transduction   >   SOCS4 Antibody   

SOCS4 Antibody

Goat Polyclonal Antibody

     
  • IHC - SOCS4 Antibody ALS14940
    Anti-SOCS4 antibody IHC of human pancreas.
  • SPECIFICATION
  • CITATIONS
  • PROTOCOLS
  • BACKGROUND
Product Information
Application
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • E=ELISA
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
IHC-P, E
Primary Accession Q8WXH5
Reactivity Human, Rabbit, Monkey, Pig, Horse, Bovine, Dog
Host Goat
Clonality Polyclonal
Calculated MW 51kDa
Dilution ELISA (1:32000), IHC-P (3.75 µg/ml),
Additional Information
Gene ID 122809
Other Names Suppressor of cytokine signaling 4, SOCS-4, Suppressor of cytokine signaling 7, SOCS-7, SOCS4, SOCS7
Target/Specificity Human SOCS4. Both variants represent identical protein (NP_543143.1 and NP_955453.1).
Reconstitution & Storage Store at -20°C. Minimize freezing and thawing.
PrecautionsSOCS4 Antibody is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Name SOCS4
Synonyms SOCS7
Function SOCS family proteins form part of a classical negative feedback system that regulates cytokine signal transduction. Substrate-recognition component of a SCF-like ECS (Elongin BC- CUL2/5-SOCS-box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins. Inhibits EGF signaling by mediating the degradation of the Tyr-phosphorylated EGF receptor/EGFR.
Research Areas
Citations (0)

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Background

SOCS family proteins form part of a classical negative feedback system that regulates cytokine signal transduction. Substrate-recognition component of a SCF-like ECS (Elongin BC- CUL2/5-SOCS-box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins. Inhibits EGF signaling by mediating the degradation of the Tyr-phosphorylated EGF receptor/EGFR.

References

Hilton D.J.,et al.Submitted (SEP-2001) to the EMBL/GenBank/DDBJ databases.
Kario E.,et al.J. Biol. Chem. 280:7038-7048(2005).
Bullock A.N.,et al.Structure 15:1493-1504(2007).

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$ 395.00
Cat# ALS14940
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