SOCS4 Antibody
Goat Polyclonal Antibody
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Application
| IHC-P, E |
---|---|
Primary Accession | Q8WXH5 |
Reactivity | Human, Rabbit, Monkey, Pig, Horse, Bovine, Dog |
Host | Goat |
Clonality | Polyclonal |
Calculated MW | 51kDa |
Dilution | ELISA (1:32000), IHC-P (3.75 µg/ml), |
Gene ID | 122809 |
---|---|
Other Names | Suppressor of cytokine signaling 4, SOCS-4, Suppressor of cytokine signaling 7, SOCS-7, SOCS4, SOCS7 |
Target/Specificity | Human SOCS4. Both variants represent identical protein (NP_543143.1 and NP_955453.1). |
Reconstitution & Storage | Store at -20°C. Minimize freezing and thawing. |
Precautions | SOCS4 Antibody is for research use only and not for use in diagnostic or therapeutic procedures. |
Name | SOCS4 |
---|---|
Synonyms | SOCS7 |
Function | SOCS family proteins form part of a classical negative feedback system that regulates cytokine signal transduction. Substrate- recognition component of a SCF-like ECS (Elongin BC-CUL2/5-SOCS-box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins. Inhibits EGF signaling by mediating the degradation of the Tyr-phosphorylated EGF receptor/EGFR. |
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Provided below are standard protocols that you may find useful for product applications.
Background
SOCS family proteins form part of a classical negative feedback system that regulates cytokine signal transduction. Substrate-recognition component of a SCF-like ECS (Elongin BC- CUL2/5-SOCS-box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins. Inhibits EGF signaling by mediating the degradation of the Tyr-phosphorylated EGF receptor/EGFR.
References
Hilton D.J.,et al.Submitted (SEP-2001) to the EMBL/GenBank/DDBJ databases.
Kario E.,et al.J. Biol. Chem. 280:7038-7048(2005).
Bullock A.N.,et al.Structure 15:1493-1504(2007).
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