|Application ||IHC-P, E|
|Reactivity||Human, Mouse, Rat, Rabbit, Hamster, Monkey, Dog|
|Dilution||ELISA (1:32000), IHC-P (3.75 µg/ml),|
|Other Names||E3 ubiquitin-protein ligase TRIM39, 6.3.2.-, RING finger protein 23, Testis-abundant finger protein, Tripartite motif-containing protein 39, TRIM39, RNF23, TFP|
|Target/Specificity||Human TRIM39 / RNF23. This antibody is expected to recognise both reported isoforms (NP_067076.2 and NP_742013.1).|
|Reconstitution & Storage||Store at -20°C. Minimize freezing and thawing.|
|Precautions||TRIM39 / RNF23 Antibody (C-Terminus) is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||E3 ubiquitin-protein ligase. May facilitate apoptosis by inhibiting APC/C-Cdh1-mediated poly-ubiquitination and subsequent proteasome-mediated degradation of the pro-apoptotic protein MOAP1.|
|Cellular Location||Cytoplasm, cytosol. Mitochondrion. Note=Found predominantly in the cytosol. Partial shift from the cytosol to the mitochondria when colocalized with MOAP1|
|Tissue Location||Ubiquitous; highly expressed in brain, heart, kidney, liver, skeletal muscle, spleen and testis|
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Provided below are standard protocols that you may find useful for product applications.
E3 ubiquitin-protein ligase. May facilitate apoptosis by inhibiting APC/C-Cdh1-mediated poly-ubiquitination and subsequent proteasome-mediated degradation of the pro-apoptotic protein MOAP1.
Orimo A.,et al.Biochem. Biophys. Res. Commun. 276:45-51(2000).
Kalnine N.,et al.Submitted (MAY-2003) to the EMBL/GenBank/DDBJ databases.
Shiina T.,et al.Submitted (MAY-2003) to the EMBL/GenBank/DDBJ databases.
Ota T.,et al.Nat. Genet. 36:40-45(2004).
Shiina T.,et al.Genetics 173:1555-1570(2006).
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