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>   home   >   Products   >   Primary Antibodies   >   Signal Transduction   >   INADL / PATJ Antibody (N-Terminus)   

INADL / PATJ Antibody (N-Terminus)

Goat Polyclonal Antibody

     
  • IHC - INADL / PATJ Antibody (N-Terminus) ALS14942
    Anti-INADL antibody IHC of human testis.
  • SPECIFICATION
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Product Information
Application
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • E=ELISA
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
IHC-P, E
Primary Accession Q8NI35
Reactivity Human, Rabbit, Monkey, Bovine
Host Goat
Clonality Polyclonal
Calculated MW 196kDa
Dilution ELISA (1:32000), IHC-P (3.75 µg/ml),
Additional Information
Gene ID 10207
Other Names InaD-like protein, Inadl protein, hINADL, Pals1-associated tight junction protein, Protein associated to tight junctions, INADL, PATJ
Target/Specificity Human INADL.
Reconstitution & Storage Store at -20°C. Minimize freezing and thawing.
PrecautionsINADL / PATJ Antibody (N-Terminus) is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Name PATJ {ECO:0000303|PubMed:22006950, ECO:0000312|HGNC:HGNC:28881}
Function Scaffolding protein that may bring different proteins into adjacent positions at the cell membrane. May regulate protein targeting, cell polarity and integrity of tight junctions. May regulate the surface expression and/or function of ASIC3 in sensory neurons. May recruit ARHGEF18 to apical cell-cell boundaries (PubMed:22006950).
Cellular Location Cell junction, tight junction. Apical cell membrane {ECO:0000250|UniProtKB:Q63ZW7}; Peripheral membrane protein {ECO:0000250|UniProtKB:Q63ZW7}. Cytoplasm, perinuclear region {ECO:0000250|UniProtKB:Q63ZW7}. Cell membrane {ECO:0000250|UniProtKB:Q63ZW7}; Peripheral membrane protein {ECO:0000250|UniProtKB:Q63ZW7}. Note=Localized in the paranodal region of myelinating Schwann cells (By similarity). Membrane- associated. Localizes to tight junctions in epithelial cells (PubMed:22006950). Also found at the apical plasma membrane {ECO:0000250|UniProtKB:Q63ZW7, ECO:0000269|PubMed:22006950}
Tissue Location Expressed in bladder, testis, ovary, small intestine, colon, heart, skeletal muscle, pancreas and cerebellum in the brain.
Research Areas
Citations (0)

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Background

Scaffolding protein that may bring different proteins into adjacent positions at the cell membrane. May regulate protein targeting, cell polarity and integrity of tight junctions. May regulate the surface expression and/or function of ASIC3 in sensory neurons.

References

Philipp S.,et al.FEBS Lett. 413:243-248(1997).
Soejima H.,et al.Genomics 74:115-120(2001).
Roh M.H.,et al.J. Cell Biol. 157:161-172(2002).
Gregory S.G.,et al.Nature 441:315-321(2006).
Lemmers C.,et al.J. Biol. Chem. 277:25408-25415(2002).

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$ 395.00
Cat# ALS14942
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