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INADL / PATJ Antibody (N-Terminus)
Goat Polyclonal Antibody
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Application 
| IHC-P, E |
|---|---|
| Primary Accession | Q8NI35 |
| Reactivity | Human, Rabbit, Monkey, Bovine |
| Host | Goat |
| Clonality | Polyclonal |
| Calculated MW | 196kDa |
| Dilution | ELISA (1:32000), IHC-P (3.75 µg/ml), |
| Other Names | InaD-like protein, Inadl protein, hINADL, Pals1-associated tight junction protein, Protein associated to tight junctions, INADL, PATJ |
|---|---|
| Target/Specificity | Human INADL. |
| Reconstitution & Storage | Store at -20°C. Minimize freezing and thawing. |
| Precautions | INADL / PATJ Antibody (N-Terminus) is for research use only and not for use in diagnostic or therapeutic procedures. |
| Name | PATJ {ECO:0000303|PubMed:22006950, ECO:0000312|HGNC:HGNC:28881} |
|---|---|
| Function | Scaffolding protein that facilitates the localization of proteins to the cell membrane (PubMed:11927608, PubMed:16678097, PubMed:22006950). Required for the correct formation of tight junctions and epithelial apico-basal polarity (PubMed:11927608, PubMed:16678097). Positively regulates epithelial cell microtubule elongation and cell migration, possibly via facilitating localization of PRKCI/aPKC and PAR3D/PAR3 at the leading edge of migrating cells (By similarity). Plays a role in the correct reorientation of the microtubule-organizing center during epithelial migration (By similarity). May regulate the surface expression and/or function of ASIC3 in sensory neurons (By similarity). May recruit ARHGEF18 to apical cell-cell boundaries (PubMed:22006950). |
| Cellular Location | Cell junction, tight junction. Apical cell membrane; Peripheral membrane protein. Cytoplasm, perinuclear region. Note=Localizes to the apical region at the start of epithelial cell polarization then locates to tight junctions as polarization is completed (PubMed:11964389). Localized in the paranodal region of myelinating Schwann cells (By similarity) Localized to the leading edge of the actin cortex of migrating epithelia cells (By similarity). {ECO:0000250|UniProtKB:E2QYC9, ECO:0000250|UniProtKB:Q63ZW7} |
| Tissue Location | Expressed in renal tubules (at protein level) (PubMed:19755384). Expressed in bladder, testis, ovary, small intestine, colon, heart, skeletal muscle, pancreas and cerebellum in the brain. |
Thousands of laboratories across the world have published research that depended on the performance of antibodies from Abcepta to advance their research. Check out links to articles that cite our products in major peer-reviewed journals, organized by research category.
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Provided below are standard protocols that you may find useful for product applications.
Background
Scaffolding protein that may bring different proteins into adjacent positions at the cell membrane. May regulate protein targeting, cell polarity and integrity of tight junctions. May regulate the surface expression and/or function of ASIC3 in sensory neurons.
References
Philipp S.,et al.FEBS Lett. 413:243-248(1997).
Soejima H.,et al.Genomics 74:115-120(2001).
Roh M.H.,et al.J. Cell Biol. 157:161-172(2002).
Gregory S.G.,et al.Nature 441:315-321(2006).
Lemmers C.,et al.J. Biol. Chem. 277:25408-25415(2002).
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