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ADRM1 Antibody (clone 3D11)

Mouse Monoclonal Antibody

     
  • WB - ADRM1 Antibody (clone 3D11) ALS14948
    ADRM1 monoclonal antibody (M02), clone 3D11. Western blot of ADRM1 expression in HeLa.
    detail
  • WB - ADRM1 Antibody (clone 3D11) ALS14948
    Western blot of ADRM1 expression in transfected 293T cell line by ADRM1 monoclonal antibody...
    detail
  • SPECIFICATION
  • CITATIONS
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Product Information
Application
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • E=ELISA
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
WB, IHC-P, E
Primary Accession Q16186
Reactivity Human
Host Mouse
Clonality Monoclonal
Clone Names 3D11
Calculated MW 42kDa
Dilution IHC-P (10 µg/ml), WB (1:500-1:1000),
Additional Information
Gene ID 11047
Other Names Proteasomal ubiquitin receptor ADRM1, 110 kDa cell membrane glycoprotein, Gp110, Adhesion-regulating molecule 1, ARM-1, Proteasome regulatory particle non-ATPase 13, hRpn13, Rpn13 homolog, ADRM1, GP110
Target/Specificity Human ADRM1
Reconstitution & Storage Store at -20°C or lower. Aliquot to avoid repeated freezing and thawing.
PrecautionsADRM1 Antibody (clone 3D11) is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Name ADRM1
Synonyms GP110
Function Component of the 26S proteasome, a multiprotein complex involved in the ATP-dependent degradation of ubiquitinated proteins (PubMed:16815440, PubMed:16906146, PubMed:16990800, PubMed:17139257, PubMed:18497817, PubMed:24752541, PubMed:25702870, PubMed:25702872). This complex plays a key role in the maintenance of protein homeostasis by removing misfolded or damaged proteins, which could impair cellular functions, and by removing proteins whose functions are no longer required (PubMed:16815440, PubMed:16906146, PubMed:16990800, PubMed:17139257, PubMed:18497817, PubMed:24752541, PubMed:25702870, PubMed:25702872). Therefore, the proteasome participates in numerous cellular processes, including cell cycle progression, apoptosis, or DNA damage repair (PubMed:16815440, PubMed:16906146, PubMed:16990800, PubMed:17139257, PubMed:18497817, PubMed:24752541, PubMed:25702870, PubMed:25702872). Within the complex, functions as a proteasomal ubiquitin receptor (PubMed:18497817). Engages and activates 19S- associated deubiquitinases UCHL5 and PSMD14 during protein degradation (PubMed:16906146, PubMed:16990800, PubMed:17139257, PubMed:24752541). UCHL5 reversibly associate with the 19S regulatory particle whereas PSMD14 is an intrinsic subunit of the proteasome lid subcomplex (PubMed:16906146, PubMed:16990800, PubMed:17139257, PubMed:24752541).
Cellular Location Cytoplasm. Nucleus
Research Areas
Citations (0)
citation

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Background

Functions as a proteasomal ubiquitin receptor. Recruits the deubiquitinating enzyme UCHL5 at the 26S proteasome and promotes its activity.

References

Shimada S.,et al.Cancer Res. 54:3831-3836(1994).
Hamazaki J.,et al.EMBO J. 25:4524-4536(2006).
Deloukas P.,et al.Nature 414:865-871(2001).
Qiu X.-B.,et al.EMBO J. 25:5742-5753(2006).
Joergensen J.P.,et al.J. Mol. Biol. 360:1043-1052(2006).

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Discontinued
Cat# ALS14948
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