|Application ||IHC-P, E|
|Reactivity||Human, Mouse, Rat, Hamster, Monkey, Pig, Chicken, Horse, Bovine, Dog|
|Dilution||ELISA (1:16000), IHC-P (3.75 µg/ml),|
|Other Names||E3 ubiquitin-protein ligase MARCH6, 6.3.2.-, Doa10 homolog, Membrane-associated RING finger protein 6, Membrane-associated RING-CH protein VI, MARCH-VI, Protein TEB-4, RING finger protein 176, MARCH6, KIAA0597, RNF176, TEB4|
|Reconstitution & Storage||Store at -20°C. Minimize freezing and thawing.|
|Precautions||MARCH6 / DOA10 Antibody (aa886-898) is for research use only and not for use in diagnostic or therapeutic procedures.|
|Synonyms||KIAA0597, RNF176, TEB4|
|Function||E3 ubiquitin-protein ligase that promotes ubiquitination of DIO2, leading to its degradation. E3 ubiquitin ligases accept ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester and then directly transfer the ubiquitin to targeted substrates. May cooperate with UBE2G1.|
|Cellular Location||Endoplasmic reticulum membrane; Multi-pass membrane protein|
|Tissue Location||Present in brain (at protein level).|
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Provided below are standard protocols that you may find useful for product applications.
E3 ubiquitin-protein ligase that promotes ubiquitination of DIO2, leading to its degradation. E3 ubiquitin ligases accept ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester and then directly transfer the ubiquitin to targeted substrates. May cooperate with UBE2G1.
Nagase T.,et al.DNA Res. 5:31-39(1998).
Ota T.,et al.Nat. Genet. 36:40-45(2004).
Schmutz J.,et al.Nature 431:268-274(2004).
Mural R.J.,et al.Submitted (SEP-2005) to the EMBL/GenBank/DDBJ databases.
Simmons A.D.,et al.Submitted (JUN-1997) to the EMBL/GenBank/DDBJ databases.
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