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MARCH6 / DOA10 Antibody (aa886-898)

Goat Polyclonal Antibody

     
  • IHC - MARCH6 / DOA10 Antibody (aa886-898) ALS14951
    Anti-MARCH6 antibody IHC of human tonsil.
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  • SPECIFICATION
  • CITATIONS
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  • BACKGROUND
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Product Information
Application
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • E=ELISA
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
IHC-P, E
Primary Accession O60337
Reactivity Human, Mouse, Rat, Hamster, Monkey, Pig, Chicken, Horse, Bovine, Dog
Host Goat
Clonality Polyclonal
Calculated MW 103kDa
Dilution ELISA (1:16000), IHC-P (3.75 µg/ml),
Additional Information
Gene ID 10299
Other Names E3 ubiquitin-protein ligase MARCH6, 6.3.2.-, Doa10 homolog, Membrane-associated RING finger protein 6, Membrane-associated RING-CH protein VI, MARCH-VI, Protein TEB-4, RING finger protein 176, MARCH6, KIAA0597, RNF176, TEB4
Target/Specificity Human MARCH6.
Reconstitution & Storage Store at -20°C. Minimize freezing and thawing.
PrecautionsMARCH6 / DOA10 Antibody (aa886-898) is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Name MARCHF6 (HGNC:30550)
Function E3 ubiquitin-protein ligase that promotes 'Lys-48'-linked ubiquitination of target proteins, leading to their proteasomal degradation (PubMed:15673284). Promotes ubiquitination of DIO2, leading to its degradation (PubMed:19651899). Promotes ubiquitination of SQLE, leading to its degradation (PubMed:24449766). E3 ubiquitin ligases accept ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester and then directly transfer the ubiquitin to targeted substrates. May cooperate with UBE2G1 (PubMed:15673284).
Cellular Location Endoplasmic reticulum membrane; Multi-pass membrane protein
Tissue Location Present in brain (at protein level).
Research Areas
Citations (0)
citation

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Background

E3 ubiquitin-protein ligase that promotes ubiquitination of DIO2, leading to its degradation. E3 ubiquitin ligases accept ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester and then directly transfer the ubiquitin to targeted substrates. May cooperate with UBE2G1.

References

Nagase T.,et al.DNA Res. 5:31-39(1998).
Ota T.,et al.Nat. Genet. 36:40-45(2004).
Schmutz J.,et al.Nature 431:268-274(2004).
Mural R.J.,et al.Submitted (SEP-2005) to the EMBL/GenBank/DDBJ databases.
Simmons A.D.,et al.Submitted (JUN-1997) to the EMBL/GenBank/DDBJ databases.

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Discontinued
Cat# ALS14951
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