|Application ||IHC-P, E|
|Calculated MW||23012 Da|
|Dilution||ELISA (1:8000), IHC-P (3.75 µg/ml),|
|Other Names||DNA dC->dU-editing enzyme APOBEC-3A, A3A, 3.5.4.-, Phorbolin-1, APOBEC3A|
|Reconstitution & Storage||Store at -20°C. Minimize freezing and thawing.|
|Precautions||APOBEC3A Antibody (Internal) is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||DNA deaminase (cytidine deaminase) with restriction activity against viruses, foreign DNA and mobility of retrotransposons. Exhibits antiviral activity against adeno- associated virus (AAV) and human T-cell leukemia virus type 1 (HTLV-1) and may inhibit the mobility of LTR and non-LTR retrotransposons. Selectively targets single-stranded DNA and can deaminate both methylcytosine and cytosine in foreign DNA. Can induce somatic hypermutation in the nuclear and mitochondrial DNA. May also play a role in the epigenetic regulation of gene expression through the process of active DNA demethylation.|
|Cellular Location||Nucleus. Cytoplasm.|
|Tissue Location||Expressed in peripheral leukocytes with higher expression in CD14-positive phagocytic cells. Highly expressed in keratinocytes and in periphery blood monocytes. Also detected in non-lymphoid tissues including lung and adipose tissues. Found at high levels in colorectal adenocarcinoma, Burkitt's lymphoma and chronic myelogenous leukemia.|
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