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MARCH7 / Axotrophin Antibody (Internal)
Goat Polyclonal Antibody
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Application 
| IHC-P, E |
|---|---|
| Primary Accession | Q9H992 |
| Reactivity | Human, Rat, Rabbit, Monkey, Horse |
| Host | Goat |
| Clonality | Polyclonal |
| Calculated MW | 78kDa |
| Dilution | ELISA (1:4000), IHC-P (3.75 µg/ml), |
| Gene ID | 64844 |
|---|---|
| Other Names | E3 ubiquitin-protein ligase MARCH7, 6.3.2.-, Axotrophin, Membrane-associated RING finger protein 7, Membrane-associated RING-CH protein VII, MARCH-VII, RING finger protein 177, MARCH7, AXOT, RNF177 |
| Target/Specificity | Human MARCH7 / Axotrophin. |
| Reconstitution & Storage | Store at -20°C. Minimize freezing and thawing. |
| Precautions | MARCH7 / Axotrophin Antibody (Internal) is for research use only and not for use in diagnostic or therapeutic procedures. |
| Name | MARCHF7 (HGNC:17393) |
|---|---|
| Synonyms | AXOT, MARCH7, RNF177 |
| Function | E3 ubiquitin-protein ligase which may specifically enhance the E2 activity of HIP2. E3 ubiquitin ligases accept ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester and then directly transfer the ubiquitin to targeted substrates (PubMed:16868077). May be involved in T-cell proliferation by regulating LIF secretion (By similarity). May play a role in lysosome homeostasis (PubMed:31270356). Promotes 'Lys-6', 'Lys-11' and 'Lys-63'- linked mixed polyubiquitination on ATG14 leading to the inhibition of autophagy by impairing the interaction between ATG14 and STX7 (PubMed:37632749). Participates in the dopamine-mediated negative regulation of the NLRP3 inflammasome by promoting its uibiquitination and subsequent degradation (PubMed:25594175). |
| Cellular Location | Cytoplasm. |
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Provided below are standard protocols that you may find useful for product applications.
Background
E3 ubiquitin-protein ligase which may specifically enhance the E2 activity of HIP2. E3 ubiquitin ligases accept ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester and then directly transfer the ubiquitin to targeted substrates.
References
Ota T.,et al.Nat. Genet. 36:40-45(2004).
Suzuki Y.,et al.Submitted (APR-2005) to the EMBL/GenBank/DDBJ databases.
Hillier L.W.,et al.Nature 434:724-731(2005).
Mural R.J.,et al.Submitted (SEP-2005) to the EMBL/GenBank/DDBJ databases.
Metcalfe S.M.,et al.FEBS Lett. 579:609-614(2005).
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