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DSP / Desmoplakin Antibody (Internal)

Goat Polyclonal Antibody

     
  • IHC - DSP / Desmoplakin Antibody (Internal) ALS14965
    Anti-DSP / Desmoplakin antibody IHC of human heart.
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  • SPECIFICATION
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Product Information
Application
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • E=ELISA
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
IHC-P, E
Primary Accession P15924
Reactivity Human
Host Goat
Clonality Polyclonal
Calculated MW 332kDa
Dilution ELISA (1:4000), IHC-P (3.75 µg/ml),
Additional Information
Gene ID 1832
Other Names Desmoplakin, DP, 250/210 kDa paraneoplastic pemphigus antigen, DSP
Target/Specificity Human DSP / Desmoplakin. This antibody is expected to recognize reported isoform I (NP_004406.2) only.
Reconstitution & Storage Store at -20°C. Minimize freezing and thawing.
PrecautionsDSP / Desmoplakin Antibody (Internal) is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Name DSP
Function Major high molecular weight protein of desmosomes. Regulates profibrotic gene expression in cardiomyocytes via activation of the MAPK14/p38 MAPK signaling cascade and increase in TGFB1 protein abundance (By similarity).
Cellular Location Cell junction, desmosome {ECO:0000250|UniProtKB:E9Q557}. Cell membrane {ECO:0000250|UniProtKB:E9Q557}. Note=Localizes at the intercalated disk in cardiomyocytes. {ECO:0000250|UniProtKB:E9Q557}
Tissue Location Expressed in oral mucosa (at protein level) (PubMed:30479852). Expressed in arrector pili muscle (at protein level) (PubMed:29034528). [Isoform DPII]: Resides predominantly in tissues and cells of stratified origin
Volume 500 µl
Research Areas
Citations (0)
citation

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Background

Major high molecular weight protein of desmosomes. Involved in the organization of the desmosomal cadherin- plakoglobin complexes into discrete plasma membrane domains and in the anchoring of intermediate filaments to the desmosomes.

References

Virata M.L.A.,et al.Proc. Natl. Acad. Sci. U.S.A. 89:544-548(1992).
Cabral R.M.,et al.Cell Tissue Res. 341:121-129(2010).
Mungall A.J.,et al.Nature 425:805-811(2003).
Green K.J.,et al.J. Biol. Chem. 265:2603-2612(1990).
Green K.J.,et al.J. Biol. Chem. 265:11406-11407(1990).

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$ 467.50
Cat# ALS14965
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