|Application ||IHC-P, E|
|Dilution||ELISA (1:4000), IHC-P (3.75 µg/ml),|
|Other Names||Desmoplakin, DP, 250/210 kDa paraneoplastic pemphigus antigen, DSP|
|Target/Specificity||Human DSP / Desmoplakin. This antibody is expected to recognize reported isoform I (NP_004406.2) only.|
|Reconstitution & Storage||Store at -20°C. Minimize freezing and thawing.|
|Precautions||DSP / Desmoplakin Antibody (Internal) is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||Major high molecular weight protein of desmosomes. Involved in the organization of the desmosomal cadherin- plakoglobin complexes into discrete plasma membrane domains and in the anchoring of intermediate filaments to the desmosomes.|
|Cellular Location||Cell junction, desmosome. Cytoplasm, cytoskeleton. Note=Innermost portion of the desmosomal plaque. Colocalizes with epidermal KRT5-KRT14 and simple KRT8-KRT18 keratins and VIM intermediate filaments network|
|Tissue Location||Isoform DPI is apparently an obligate constituent of all desmosomes. Isoform DPII resides predominantly in tissues and cells of stratified origin|
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Provided below are standard protocols that you may find useful for product applications.
Major high molecular weight protein of desmosomes. Involved in the organization of the desmosomal cadherin- plakoglobin complexes into discrete plasma membrane domains and in the anchoring of intermediate filaments to the desmosomes.
Virata M.L.A.,et al.Proc. Natl. Acad. Sci. U.S.A. 89:544-548(1992).
Cabral R.M.,et al.Cell Tissue Res. 341:121-129(2010).
Mungall A.J.,et al.Nature 425:805-811(2003).
Green K.J.,et al.J. Biol. Chem. 265:2603-2612(1990).
Green K.J.,et al.J. Biol. Chem. 265:11406-11407(1990).
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