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FKBP4 / FKBP52 Antibody (clone Hi52C)
Mouse Monoclonal Antibody
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Application 
| WB, IHC-P, IF, IP |
|---|---|
| Primary Accession | Q02790 |
| Reactivity | Human, Mouse, Rat, Hamster, Dog |
| Host | Mouse |
| Clonality | Monoclonal |
| Clone Names | Hi52C |
| Calculated MW | 52kDa |
| Dilution | IHC-P (10 µg/ml), WB (1:2000), |
| Gene ID | 2288 |
|---|---|
| Other Names | Peptidyl-prolyl cis-trans isomerase FKBP4, PPIase FKBP4, 5.2.1.8, 51 kDa FK506-binding protein, FKBP51, 52 kDa FK506-binding protein, 52 kDa FKBP, FKBP-52, 59 kDa immunophilin, p59, FK506-binding protein 4, FKBP-4, FKBP59, HSP-binding immunophilin, HBI, Immunophilin FKBP52, Rotamase, Peptidyl-prolyl cis-trans isomerase FKBP4, N-terminally processed, FKBP4, FKBP52 |
| Target/Specificity | Detects an ~52 kD protein representing FKBP52 in HeLa cell lysate. Also detects FKBP52 in whole tissue extracts from rat kidney and rat and mouse testes. Heavy chain migrates close to FKBP52 on SDS-PAGE. |
| Reconstitution & Storage | Short term 4°C, long term aliquot and store at -20°C, avoid freeze thaw cycles. |
| Precautions | FKBP4 / FKBP52 Antibody (clone Hi52C) is for research use only and not for use in diagnostic or therapeutic procedures. |
| Name | FKBP4 |
|---|---|
| Synonyms | FKBP52 |
| Function | Immunophilin protein with PPIase and co-chaperone activities. Component of steroid receptors heterocomplexes through interaction with heat-shock protein 90 (HSP90). May play a role in the intracellular trafficking of heterooligomeric forms of steroid hormone receptors between cytoplasm and nuclear compartments. The isomerase activity controls neuronal growth cones via regulation of TRPC1 channel opening. Acts also as a regulator of microtubule dynamics by inhibiting MAPT/TAU ability to promote microtubule assembly. May have a protective role against oxidative stress in mitochondria. |
| Cellular Location | Cytoplasm, cytosol. Mitochondrion. Nucleus {ECO:0000250|UniProtKB:P30416}. Cytoplasm, cytoskeleton {ECO:0000250|UniProtKB:Q9QVC8}. Cell projection, axon {ECO:0000250|UniProtKB:Q9QVC8}. Note=Shuttles from mitochondria to nucleus; co-localizes in mitochondria with the glucocorticoid receptor (PubMed:21730050). Colocalized with MAPT/TAU in the distal part of the primary cortical neurons (By similarity) {ECO:0000250|UniProtKB:Q9QVC8, ECO:0000269|PubMed:21730050} |
| Tissue Location | Widely expressed.. |
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Provided below are standard protocols that you may find useful for product applications.
Background
Immunophilin protein with PPIase and co-chaperone activities. Component of steroid receptors heterocomplexes through interaction with heat-shock protein 90 (HSP90). May play a role in the intracellular trafficking of heterooligomeric forms of steroid hormone receptors between cytoplasm and nuclear compartments. The isomerase activity controls neuronal growth cones via regulation of TRPC1 channel opening. Acts also as a regulator of microtubule dynamics by inhibiting MAPT/TAU ability to promote microtubule assembly. May have a protective role against oxidative stress in mitochondria.
References
Peattie D.A.,et al.Proc. Natl. Acad. Sci. U.S.A. 89:10974-10978(1992).
Scherer S.E.,et al.Nature 440:346-351(2006).
Mural R.J.,et al.Submitted (SEP-2005) to the EMBL/GenBank/DDBJ databases.
Bienvenut W.V.,et al.Submitted (JAN-2010) to UniProtKB.
Tai P.-K.K.,et al.Science 256:1315-1318(1992).
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