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>   home   >   Products   >   Primary Antibodies   >   Signal Transduction   >   FKBP4 / FKBP52 Antibody (clone Hi52C)   

FKBP4 / FKBP52 Antibody (clone Hi52C)

Mouse Monoclonal Antibody

     
  • IHC - FKBP4 / FKBP52 Antibody (clone Hi52C) ALS14973
    Prostate tissue was histologically stained with antibodies specific for FKBP52.
  • IF - FKBP4 / FKBP52 Antibody (clone Hi52C) ALS14973
    FKBP52 (Hi52C), MCF-7 cells.
  • IHC - FKBP4 / FKBP52 Antibody (clone Hi52C) ALS14973
    Anti-FKBP52 antibody IHC of human prostate.
  • SPECIFICATION
  • CITATIONS
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  • BACKGROUND
Product Information
Application
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • E=ELISA
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
WB, IHC-P, IF, IP
Primary Accession Q02790
Reactivity Human, Mouse, Rat, Hamster, Dog
Host Mouse
Clonality Monoclonal
Clone Names Hi52C
Calculated MW 52kDa
Dilution IHC-P (10 µg/ml), WB (1:2000),
Additional Information
Gene ID 2288
Other Names Peptidyl-prolyl cis-trans isomerase FKBP4, PPIase FKBP4, 5.2.1.8, 51 kDa FK506-binding protein, FKBP51, 52 kDa FK506-binding protein, 52 kDa FKBP, FKBP-52, 59 kDa immunophilin, p59, FK506-binding protein 4, FKBP-4, FKBP59, HSP-binding immunophilin, HBI, Immunophilin FKBP52, Rotamase, Peptidyl-prolyl cis-trans isomerase FKBP4, N-terminally processed, FKBP4, FKBP52
Target/Specificity Detects an ~52 kD protein representing FKBP52 in HeLa cell lysate. Also detects FKBP52 in whole tissue extracts from rat kidney and rat and mouse testes. Heavy chain migrates close to FKBP52 on SDS-PAGE.
Reconstitution & Storage Short term 4°C, long term aliquot and store at -20°C, avoid freeze thaw cycles.
PrecautionsFKBP4 / FKBP52 Antibody (clone Hi52C) is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Name FKBP4
Synonyms FKBP52
Function Immunophilin protein with PPIase and co-chaperone activities. Component of steroid receptors heterocomplexes through interaction with heat-shock protein 90 (HSP90). May play a role in the intracellular trafficking of heterooligomeric forms of steroid hormone receptors between cytoplasm and nuclear compartments. The isomerase activity controls neuronal growth cones via regulation of TRPC1 channel opening. Acts also as a regulator of microtubule dynamics by inhibiting MAPT/TAU ability to promote microtubule assembly. May have a protective role against oxidative stress in mitochondria.
Cellular Location Cytoplasm, cytosol. Mitochondrion. Nucleus. Cytoplasm, cytoskeleton Note=Shuttles from mitochondria to nucleus; co-localizes in mitochondria with the glucocorticoid receptor
Tissue Location Widely expressed.
Research Areas
Citations (0)

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Background

Immunophilin protein with PPIase and co-chaperone activities. Component of steroid receptors heterocomplexes through interaction with heat-shock protein 90 (HSP90). May play a role in the intracellular trafficking of heterooligomeric forms of steroid hormone receptors between cytoplasm and nuclear compartments. The isomerase activity controls neuronal growth cones via regulation of TRPC1 channel opening. Acts also as a regulator of microtubule dynamics by inhibiting MAPT/TAU ability to promote microtubule assembly. May have a protective role against oxidative stress in mitochondria.

References

Peattie D.A.,et al.Proc. Natl. Acad. Sci. U.S.A. 89:10974-10978(1992).
Scherer S.E.,et al.Nature 440:346-351(2006).
Mural R.J.,et al.Submitted (SEP-2005) to the EMBL/GenBank/DDBJ databases.
Bienvenut W.V.,et al.Submitted (JAN-2010) to UniProtKB.
Tai P.-K.K.,et al.Science 256:1315-1318(1992).

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$ 395.00
Cat# ALS14973
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