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PTGES3 Antibody (clone JJ6)
Mouse Monoclonal Antibody
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Application 
| WB, IHC-P, E, IP |
|---|---|
| Primary Accession | Q15185 |
| Reactivity | Human, Mouse, Rabbit, Pig, Chicken, Yeast, Guinea Pig |
| Host | Mouse |
| Clonality | Monoclonal |
| Clone Names | JJ6 |
| Calculated MW | 19kDa |
| Dilution | IHC-P (10 µg/ml), WB (1:2000), |
| Gene ID | 10728 |
|---|---|
| Other Names | Prostaglandin E synthase 3, 5.3.99.3, Cytosolic prostaglandin E2 synthase, cPGES, Hsp90 co-chaperone, Progesterone receptor complex p23, Telomerase-binding protein p23, PTGES3, P23, TEBP |
| Target/Specificity | Detects ~23 kD protein. |
| Reconstitution & Storage | Short term 4°C, long term aliquot and store at -20°C, avoid freeze thaw cycles. |
| Precautions | PTGES3 Antibody (clone JJ6) is for research use only and not for use in diagnostic or therapeutic procedures. |
| Name | PTGES3 |
|---|---|
| Synonyms | P23, TEBP |
| Function | Cytosolic prostaglandin synthase that catalyzes the oxidoreduction of prostaglandin endoperoxide H2 (PGH2) to prostaglandin E2 (PGE2) (PubMed:10922363). Molecular chaperone that localizes to genomic response elements in a hormone-dependent manner and disrupts receptor-mediated transcriptional activation, by promoting disassembly of transcriptional regulatory complexes (PubMed:11274138, PubMed:12077419). Facilitates HIF alpha proteins hydroxylation via interaction with EGLN1/PHD2, leading to recruit EGLN1/PHD2 to the HSP90 pathway (PubMed:24711448). |
| Cellular Location | Cytoplasm {ECO:0000250|UniProtKB:Q3ZBF7}. |
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Provided below are standard protocols that you may find useful for product applications.
Background
Cytosolic prostaglandin synthase that catalyzes the oxidoreduction of prostaglandin endoperoxide H2 (PGH2) to prostaglandin E2 (PGE2) (PubMed:10922363). Molecular chaperone that localizes to genomic response elements in a hormone-dependent manner and disrupts receptor-mediated transcriptional activation, by promoting disassembly of transcriptional regulatory complexes (PubMed:11274138, PubMed:12077419). Facilitates HIF alpha proteins hydroxylation via interaction with EGLN1/PHD2, leading to recruit EGLN1/PHD2 to the HSP90 pathway (PubMed:24711448).
References
Johnson J.L.,et al.Mol. Cell. Biol. 14:1956-1963(1994).
Ota T.,et al.Nat. Genet. 36:40-45(2004).
Scherer S.E.,et al.Nature 440:346-351(2006).
Mural R.J.,et al.Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases.
Bienvenut W.V.,et al.Submitted (MAR-2009) to UniProtKB.
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