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>   home   >   Products   >   Primary Antibodies   >   Neuroscience   >   KCNJ12 / Kir2.2 Antibody (aa362-427, clone S124B-38)   

KCNJ12 / Kir2.2 Antibody (aa362-427, clone S124B-38)

Mouse Monoclonal Antibody

     
  • IF - KCNJ12 / Kir2.2 Antibody (aa362-427, clone S124B-38) ALS14985
    Kir2.2 (S24-1), Human hippocampus.
  • IF - KCNJ12 / Kir2.2 Antibody (aa362-427, clone S124B-38) ALS14985
    Kir2.2 (S24-1), Mouse back skin.
  • WB - KCNJ12 / Kir2.2 Antibody (aa362-427, clone S124B-38) ALS14985
    Kir2 2 (S24-1), Human cell line mix.
  • IHC - KCNJ12 / Kir2.2 Antibody (aa362-427, clone S124B-38) ALS14985
    Anti-KCNJ12 / Kir2.2 antibody IHC of human brain, cortex neurons.
  • SPECIFICATION
  • CITATIONS
  • PROTOCOLS
  • BACKGROUND
Product Information
Application
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • E=ELISA
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
WB, IHC-P, IF, ICC
Primary Accession Q14500
Reactivity Human, Mouse, Rat
Host Mouse
Clonality Monoclonal
Clone Names S124B-38
Calculated MW 49kDa
Dilution ICC (0.1-1 µg/ml), IHC-P (5 µg/ml), WB (1-10 µg/ml)
Additional Information
Gene ID 3768
Other Names ATP-sensitive inward rectifier potassium channel 12, Inward rectifier K(+) channel Kir2.2, IRK-2, Inward rectifier K(+) channel Kir2.2v, Potassium channel, inwardly rectifying subfamily J member 12, KCNJ12, IRK2, KCNJN1
Target/Specificity Detects ~45 kD protein. No cross reactivity against Kir2.1, or Kir2.3.
Reconstitution & Storage Short term 4°C, long term aliquot and store at -20°C, avoid freeze thaw cycles.
PrecautionsKCNJ12 / Kir2.2 Antibody (aa362-427, clone S124B-38) is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Name KCNJ12
Synonyms IRK2, KCNJN1
Function Inward rectifying potassium channel that is activated by phosphatidylinositol 4,5-bisphosphate and that probably participates in controlling the resting membrane potential in electrically excitable cells. Probably participates in establishing action potential waveform and excitability of neuronal and muscle tissues. Inward rectifier potassium channels are characterized by a greater tendency to allow potassium to flow into the cell rather than out of it. Their voltage dependence is regulated by the concentration of extracellular potassium; as external potassium is raised, the voltage range of the channel opening shifts to more positive voltages. The inward rectification is mainly due to the blockage of outward current by internal magnesium.
Cellular Location Membrane; Multi-pass membrane protein. Cell membrane; Multi-pass membrane protein
Research Areas
Citations (0)

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Background

Inward rectifying potassium channel that is activated by phosphatidylinositol 4,5-bisphosphate and that probably participates in controlling the resting membrane potential in electrically excitable cells. Probably participates in establishing action potential waveform and excitability of neuronal and muscle tissues. Inward rectifier potassium channels are characterized by a greater tendency to allow potassium to flow into the cell rather than out of it. Their voltage dependence is regulated by the concentration of extracellular potassium; as external potassium is raised, the voltage range of the channel opening shifts to more positive voltages. The inward rectification is mainly due to the blockage of outward current by internal magnesium.

References

Wible B.A.,et al.Circ. Res. 76:343-350(1995).
Namba N.,et al.FEBS Lett. 386:211-214(1996).
Kaibara M.,et al.FEBS Lett. 531:250-254(2002).
Gallagher P.G.,et al.J. Biol. Chem. 273:1339-1348(1998).
Preisig-Muller R.,et al.Proc. Natl. Acad. Sci. U.S.A. 99:7774-7779(2002).

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$ 395.00
Cat# ALS14985
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