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KCNJ12 / Kir2.2 Antibody (aa362-427, clone S124B-38)
Mouse Monoclonal Antibody
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Application 
| WB, IHC-P, IF, ICC |
|---|---|
| Primary Accession | Q14500 |
| Reactivity | Human, Mouse, Rat |
| Host | Mouse |
| Clonality | Monoclonal |
| Clone Names | S124B-38 |
| Calculated MW | 49kDa |
| Dilution | ICC (0.1-1 µg/ml), IHC-P (5 µg/ml), WB (1-10 µg/ml) |
| Gene ID | 3768 |
|---|---|
| Other Names | ATP-sensitive inward rectifier potassium channel 12, Inward rectifier K(+) channel Kir2.2, IRK-2, Inward rectifier K(+) channel Kir2.2v, Potassium channel, inwardly rectifying subfamily J member 12, KCNJ12, IRK2, KCNJN1 |
| Target/Specificity | Detects ~45 kD protein. No cross reactivity against Kir2.1, or Kir2.3. |
| Reconstitution & Storage | Short term 4°C, long term aliquot and store at -20°C, avoid freeze thaw cycles. |
| Precautions | KCNJ12 / Kir2.2 Antibody (aa362-427, clone S124B-38) is for research use only and not for use in diagnostic or therapeutic procedures. |
| Name | KCNJ12 |
|---|---|
| Synonyms | IRK2, KCNJN1 |
| Function | Inward rectifying potassium channel that is activated by phosphatidylinositol 4,5-bisphosphate and that probably participates in controlling the resting membrane potential in electrically excitable cells. Probably participates in establishing action potential waveform and excitability of neuronal and muscle tissues. Inward rectifier potassium channels are characterized by a greater tendency to allow potassium to flow into the cell rather than out of it. Their voltage dependence is regulated by the concentration of extracellular potassium; as external potassium is raised, the voltage range of the channel opening shifts to more positive voltages. The inward rectification is mainly due to the blockage of outward current by internal magnesium. |
| Cellular Location | Membrane; Multi-pass membrane protein. Cell membrane; Multi-pass membrane protein |
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Provided below are standard protocols that you may find useful for product applications.
Background
Inward rectifying potassium channel that is activated by phosphatidylinositol 4,5-bisphosphate and that probably participates in controlling the resting membrane potential in electrically excitable cells. Probably participates in establishing action potential waveform and excitability of neuronal and muscle tissues. Inward rectifier potassium channels are characterized by a greater tendency to allow potassium to flow into the cell rather than out of it. Their voltage dependence is regulated by the concentration of extracellular potassium; as external potassium is raised, the voltage range of the channel opening shifts to more positive voltages. The inward rectification is mainly due to the blockage of outward current by internal magnesium.
References
Wible B.A.,et al.Circ. Res. 76:343-350(1995).
Namba N.,et al.FEBS Lett. 386:211-214(1996).
Kaibara M.,et al.FEBS Lett. 531:250-254(2002).
Gallagher P.G.,et al.J. Biol. Chem. 273:1339-1348(1998).
Preisig-Muller R.,et al.Proc. Natl. Acad. Sci. U.S.A. 99:7774-7779(2002).
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