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KCNJ4 / Kir2.3 Antibody (aa390-445, clone S25-35)
Mouse Monoclonal Antibody
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Application 
| WB, IHC-P, IF, ICC, IP |
|---|---|
| Primary Accession | P48050 |
| Reactivity | Human, Mouse, Rat |
| Host | Mouse |
| Clonality | Monoclonal |
| Clone Names | S25-35 |
| Calculated MW | 50kDa |
| Dilution | ICC (0.1-1 µg/ml), IHC-P (5 µg/ml), IP (1-10 µg/ml), WB (1-10 µg/ml) , |
| Gene ID | 3761 |
|---|---|
| Other Names | Inward rectifier potassium channel 4, HIRK2, HRK1, Hippocampal inward rectifier, HIR, Inward rectifier K(+) channel Kir2.3, IRK-3, Potassium channel, inwardly rectifying subfamily J member 4, KCNJ4, IRK3 |
| Target/Specificity | Detects ~45 kD protein. No cross reactivity against Kir2.1, or Kir2.2. |
| Reconstitution & Storage | Short term 4°C, long term aliquot and store at -20°C, avoid freeze thaw cycles. |
| Precautions | KCNJ4 / Kir2.3 Antibody (aa390-445, clone S25-35) is for research use only and not for use in diagnostic or therapeutic procedures. |
| Name | KCNJ4 |
|---|---|
| Synonyms | IRK3 |
| Function | Inward rectifier potassium channels are characterized by a greater tendency to allow potassium to flow into the cell rather than out of it. Their voltage dependence is regulated by the concentration of extracellular potassium; as external potassium is raised, the voltage range of the channel opening shifts to more positive voltages. The inward rectification is mainly due to the blockage of outward current by internal magnesium. Can be blocked by extracellular barium and cesium (By similarity). |
| Cellular Location | Cell membrane; Multi-pass membrane protein. Postsynaptic cell membrane; Multi-pass membrane protein. Cytoplasmic vesicle membrane. Note=TAX1BP3 binding promotes dissociation of KCNJ4 from LIN7 famaly members and KCNJ4 internalization. |
| Tissue Location | Heart, skeletal muscle, and several different brain regions including the hippocampus |
Thousands of laboratories across the world have published research that depended on the performance of antibodies from Abcepta to advance their research. Check out links to articles that cite our products in major peer-reviewed journals, organized by research category.
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Provided below are standard protocols that you may find useful for product applications.
Background
Inward rectifier potassium channels are characterized by a greater tendency to allow potassium to flow into the cell rather than out of it. Their voltage dependence is regulated by the concentration of extracellular potassium; as external potassium is raised, the voltage range of the channel opening shifts to more positive voltages. The inward rectification is mainly due to the blockage of outward current by internal magnesium. Can be blocked by extracellular barium and cesium (By similarity).
References
Perier F.,et al.Proc. Natl. Acad. Sci. U.S.A. 91:6240-6244(1994).
Tang W.,et al.FEBS Lett. 348:239-243(1994).
Makhina E.N.,et al.J. Biol. Chem. 269:20468-20474(1994).
Collins J.E.,et al.Genome Biol. 5:R84.1-R84.11(2004).
Dunham I.,et al.Nature 402:489-495(1999).
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