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>   home   >   Products   >   Primary Antibodies   >   Neuroscience   >   KCNJ4 / Kir2.3 Antibody (aa390-445, clone S25-35)   

KCNJ4 / Kir2.3 Antibody (aa390-445, clone S25-35)

Mouse Monoclonal Antibody

     
  • IF - KCNJ4 / Kir2.3 Antibody (aa390-445, clone S25-35) ALS14986
    Kir2.3 (S25-35), Human hippocampus.
  • WB - KCNJ4 / Kir2.3 Antibody (aa390-445, clone S25-35) ALS14986
    Kir2 3 (S25-35), Human cell line mix.
  • IHC - KCNJ4 / Kir2.3 Antibody (aa390-445, clone S25-35) ALS14986
    Anti-KCNJ4 / Kir2.3 antibody IHC of human brain, cortex neurons.
  • SPECIFICATION
  • CITATIONS
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  • BACKGROUND
Product Information
Application
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • E=ELISA
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
WB, IHC-P, IF, ICC, IP
Primary Accession P48050
Reactivity Human, Mouse, Rat
Host Mouse
Clonality Monoclonal
Clone Names S25-35
Calculated MW 50kDa
Dilution ICC (0.1-1 µg/ml), IHC-P (5 µg/ml), IP (1-10 µg/ml), WB (1-10 µg/ml) ,
Additional Information
Gene ID 3761
Other Names Inward rectifier potassium channel 4, HIRK2, HRK1, Hippocampal inward rectifier, HIR, Inward rectifier K(+) channel Kir2.3, IRK-3, Potassium channel, inwardly rectifying subfamily J member 4, KCNJ4, IRK3
Target/Specificity Detects ~45 kD protein. No cross reactivity against Kir2.1, or Kir2.2.
Reconstitution & Storage Short term 4°C, long term aliquot and store at -20°C, avoid freeze thaw cycles.
PrecautionsKCNJ4 / Kir2.3 Antibody (aa390-445, clone S25-35) is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Name KCNJ4
Synonyms IRK3
Function Inward rectifier potassium channels are characterized by a greater tendency to allow potassium to flow into the cell rather than out of it. Their voltage dependence is regulated by the concentration of extracellular potassium; as external potassium is raised, the voltage range of the channel opening shifts to more positive voltages. The inward rectification is mainly due to the blockage of outward current by internal magnesium. Can be blocked by extracellular barium and cesium (By similarity).
Cellular Location Cell membrane; Multi-pass membrane protein. Cell junction, synapse, postsynaptic cell membrane; Multi-pass membrane protein. Cytoplasmic vesicle membrane. Note=TAX1BP3 binding promotes dissociation of KCNJ4 from LIN7 famaly members and KCNJ4 internalization
Tissue Location Heart, skeletal muscle, and several different brain regions including the hippocampus
Research Areas
Citations (0)

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Background

Inward rectifier potassium channels are characterized by a greater tendency to allow potassium to flow into the cell rather than out of it. Their voltage dependence is regulated by the concentration of extracellular potassium; as external potassium is raised, the voltage range of the channel opening shifts to more positive voltages. The inward rectification is mainly due to the blockage of outward current by internal magnesium. Can be blocked by extracellular barium and cesium (By similarity).

References

Perier F.,et al.Proc. Natl. Acad. Sci. U.S.A. 91:6240-6244(1994).
Tang W.,et al.FEBS Lett. 348:239-243(1994).
Makhina E.N.,et al.J. Biol. Chem. 269:20468-20474(1994).
Collins J.E.,et al.Genome Biol. 5:R84.1-R84.11(2004).
Dunham I.,et al.Nature 402:489-495(1999).

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$ 395.00
Cat# ALS14986
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