|Application ||WB, IHC-P|
|Reactivity||Human, Mouse, Rat, Hamster, Monkey, Sheep, Yeast, Bovine|
|Dilution||IHC-P (5 µg/ml), WB (1:1000),|
|Other Names||Heat shock protein 105 kDa, Antigen NY-CO-25, Heat shock 110 kDa protein, HSPH1, HSP105, HSP110, KIAA0201|
|Target/Specificity||Detects ~110 kD protein.|
|Reconstitution & Storage||Short term 4°C, long term aliquot and store at -20°C, avoid freeze thaw cycles.|
|Precautions||HSPH1 / HSP110 Antibody is for research use only and not for use in diagnostic or therapeutic procedures.|
|Synonyms||HSP105, HSP110, KIAA0201|
|Function||Prevents the aggregation of denatured proteins in cells under severe stress, on which the ATP levels decrease markedly. Inhibits HSPA8/HSC70 ATPase and chaperone activities (By similarity).|
|Tissue Location||Highly expressed in testis. Present at lower levels in most brain regions, except cerebellum. Overexpressed in cancer cells.|
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Provided below are standard protocols that you may find useful for product applications.
Prevents the aggregation of denatured proteins in cells under severe stress, on which the ATP levels decrease markedly. Inhibits HSPA8/HSC70 ATPase and chaperone activities (By similarity).
Ishihara K.,et al.Biochim. Biophys. Acta 1444:138-142(1999).
Scanlan M.J.,et al.Int. J. Cancer 76:652-658(1998).
Nagase T.,et al.DNA Res. 3:321-329(1996).
Ota T.,et al.Nat. Genet. 36:40-45(2004).
Dunham A.,et al.Nature 428:522-528(2004).
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