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SLC38A1 / NaT2 Antibody (clone S104-32)
Mouse Monoclonal Antibody
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Application 
| WB, IHC-P, ICC |
|---|---|
| Primary Accession | Q9H2H9 |
| Reactivity | Human, Mouse, Rat |
| Host | Mouse |
| Clonality | Monoclonal |
| Clone Names | S104-32 |
| Calculated MW | 54kDa |
| Dilution | IHC-P (10 µg/ml) |
| Gene ID | 81539 |
|---|---|
| Other Names | Sodium-coupled neutral amino acid transporter 1, Amino acid transporter A1, N-system amino acid transporter 2, Solute carrier family 38 member 1, System A amino acid transporter 1, System N amino acid transporter 1, SLC38A1, ATA1, NAT2, SAT1, SNAT1 |
| Target/Specificity | Detects ~50kDa. |
| Reconstitution & Storage | Short term 4°C, long term aliquot and store at -20°C, avoid freeze thaw cycles. |
| Precautions | SLC38A1 / NaT2 Antibody (clone S104-32) is for research use only and not for use in diagnostic or therapeutic procedures. |
| Name | SLC38A1 |
|---|---|
| Function | Symporter that cotransports short-chain neutral amino acids and sodium ions from the extraccellular to the intracellular side of the cell membrane (PubMed:20599747, PubMed:10891391). The transport is elctrogenic, pH dependent and driven by the Na(+) electrochemical gradient (PubMed:10891391). Participates in the astroglia-derived glutamine transport into GABAergic interneurons for neurotransmitter GABA de novo synthesis (By similarity). May also contributes to amino acid transport in placental trophoblasts (PubMed:20599747). Also regulates synaptic plasticity (PubMed:12388062). |
| Cellular Location | Cell membrane; Multi-pass membrane protein {ECO:0000250|UniProtKB:Q9JM15} Note=Restricted to the somatodendritic compartment of neurons. Found in the cellular processes of neurons in the developing brain {ECO:0000250|UniProtKB:Q9JM15} |
| Tissue Location | Expressed in the cerebral cortex by pyramidal and GABAergic neurons, astrocytes and other non-neuronal cells (at protein level). Expressed in placenta, heart, lung, skeletal muscle, spleen, stomach and testis (PubMed:10891391, PubMed:12388062, PubMed:15054072, PubMed:16148032). Highly expressed in cytotrophoblast cells from term placenta (PubMed:20599747). |
| Volume | 50 µl |
Thousands of laboratories across the world have published research that depended on the performance of antibodies from Abcepta to advance their research. Check out links to articles that cite our products in major peer-reviewed journals, organized by research category.
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Provided below are standard protocols that you may find useful for product applications.
Background
Functions as a sodium-dependent amino acid transporter. Mediates the saturable, pH-sensitive and electrogenic cotransport of glutamine and sodium ions with a stoichiometry of 1:1. May also transport small zwitterionic and aliphatic amino acids with a lower affinity. May supply glutamatergic and GABAergic neurons with glutamine which is required for the synthesis of the neurotransmitters glutamate and GABA.
References
Wang H.,et al.Biochem. Biophys. Res. Commun. 273:1175-1179(2000).
Xu X.,et al.Submitted (MAR-2000) to the EMBL/GenBank/DDBJ databases.
Ota T.,et al.Nat. Genet. 36:40-45(2004).
Otsuki T.,et al.DNA Res. 12:117-126(2005).
Mural R.J.,et al.Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases.
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