|Application ||WB, IHC-P, E|
|Dilution||ELISA (1:10000), IHC-P (5 µg/ml), WB (1:200)|
|Other Names||Plexin-B1, Semaphorin receptor SEP, PLXNB1, KIAA0407, PLXN5, SEP|
|Target/Specificity||Plexin B1 antibody detects endogenous levels of Plexin B1 protein. Not tested with other proteins.|
|Reconstitution & Storage||For long term storage -20°C is recommended.|
|Precautions||PLXNB1 / Plexin-B1 Antibody is for research use only and not for use in diagnostic or therapeutic procedures.|
|Synonyms||KIAA0407, PLXN5, SEP|
|Function||Receptor for SEMA4D. Plays a role in RHOA activation and subsequent changes of the actin cytoskeleton. Plays a role in axon guidance, invasive growth and cell migration.|
|Cellular Location||Isoform 1: Cell membrane; Single-pass type I membrane protein Isoform 3: Secreted.|
|Tissue Location||Highly expressed in fetal kidney, and at slightly lower levels in fetal brain, lung and liver|
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Provided below are standard protocols that you may find useful for product applications.
Receptor for SEMA4D. Plays a role in RHOA activation and subsequent changes of the actin cytoskeleton. Plays a role in axon guidance, invasive growth and cell migration.
Ishikawa K.,et al.DNA Res. 4:307-313(1997).
Tamagnone L.,et al.Cell 99:71-80(1999).
Tamagnone L.,et al.Cell 104:321-321(2001).
Maestrini E.,et al.Proc. Natl. Acad. Sci. U.S.A. 93:674-678(1996).
Mural R.J.,et al.Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases.
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