|Application ||WB, IHC-P, IF, E|
|Reactivity||Human, Mouse, Rat|
|Dilution||ELISA (1:10000), IF (1:100-1:500), IHC-P (10 µg/ml), WB (1:500-1:1000) ,|
|Other Names||Cytosolic phospholipase A2, cPLA2, Phospholipase A2 group IVA, Phospholipase A2, 18.104.22.168, Phosphatidylcholine 2-acylhydrolase, Lysophospholipase, 22.214.171.124, PLA2G4A, CPLA2, PLA2G4|
|Target/Specificity||c-PLA2 Antibody detects endogenous levels of total c-PLA2 protein.|
|Reconstitution & Storage||Long term: -20°C; Short term: +4°C; Avoid freeze-thaw cycles.|
|Precautions||PLA2G4A Antibody (aa471-520) is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||Selectively hydrolyzes arachidonyl phospholipids in the sn-2 position releasing arachidonic acid. Together with its lysophospholipid activity, it is implicated in the initiation of the inflammatory response.|
|Cellular Location||Cytoplasm. Cytoplasmic vesicle. Note=Translocates to membrane vesicles in a calcium-dependent fashion|
|Tissue Location||Expressed in various tissues such as macrophages, platelets, neutrophils, fibroblasts and lung endothelium|
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Provided below are standard protocols that you may find useful for product applications.
Selectively hydrolyzes arachidonyl phospholipids in the sn-2 position releasing arachidonic acid. Together with its lysophospholipid activity, it is implicated in the initiation of the inflammatory response.
Clark J.D.,et al.Cell 65:1043-1051(1991).
Sharp J.,et al.J. Biol. Chem. 266:14850-14853(1991).
Gregory S.G.,et al.Nature 441:315-321(2006).
Lin L.-L.,et al.Cell 72:269-278(1993).
Sharp J.D.,et al.J. Biol. Chem. 269:23250-23254(1994).
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