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EIF4EBP1 / 4EBP1 Antibody (aa30-79)

Rabbit Polyclonal Antibody

     
  • WB - EIF4EBP1 / 4EBP1 Antibody (aa30-79) ALS15009
    Western blot of extracts from Jurkat cells, treated with Insulin 0.01U/ml 15', using 4E-BP1 Antibody.
  • IHC - EIF4EBP1 / 4EBP1 Antibody (aa30-79) ALS15009
    Anti-EIF4EBP1 / 4EBP1 antibody IHC of human breast.
  • SPECIFICATION
  • CITATIONS
  • PROTOCOLS
  • BACKGROUND
Product Information
Application
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • E=ELISA
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
WB, IHC-P, E
Primary Accession Q13541
Reactivity Human, Mouse, Rat
Host Rabbit
Clonality Polyclonal
Calculated MW 13kDa
Dilution ELISA (1:5000), IHC-P (10 µg/ml), WB (1:500-1:1000)
Additional Information
Gene ID 1978
Other Names Eukaryotic translation initiation factor 4E-binding protein 1, 4E-BP1, eIF4E-binding protein 1, Phosphorylated heat- and acid-stable protein regulated by insulin 1, PHAS-I, EIF4EBP1
Target/Specificity 4E-BP1 Antibody detects endogenous levels of total 4E-BP1 protein.
Reconstitution & Storage Long term: -20°C; Short term: +4°C; Avoid freeze-thaw cycles.
PrecautionsEIF4EBP1 / 4EBP1 Antibody (aa30-79) is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Name EIF4EBP1
Function Repressor of translation initiation that regulates EIF4E activity by preventing its assembly into the eIF4F complex: hypophosphorylated form competes with EIF4G1/EIF4G3 and strongly binds to EIF4E, leading to repress translation. In contrast, hyperphosphorylated form dissociates from EIF4E, allowing interaction between EIF4G1/EIF4G3 and EIF4E, leading to initiation of translation. Mediates the regulation of protein translation by hormones, growth factors and other stimuli that signal through the MAP kinase and mTORC1 pathways.
Volume 50 µl
Research Areas
Citations (0)

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Background

Regulates eIF4E activity by preventing its assembly into the eIF4F complex: hypophosphorylated form competes with EIF4G1/EIF4G3 and strongly binds to EIF4E, leading to repress translation. Mediates the regulation of protein translation by hormones, growth factors and other stimuli that signal through the MAP kinase and mTORC1 pathways.

References

Pause A.,et al.Nature 371:762-767(1994).
Ito M.,et al.Submitted (JUN-2000) to the EMBL/GenBank/DDBJ databases.
Kalnine N.,et al.Submitted (MAY-2003) to the EMBL/GenBank/DDBJ databases.
Ebert L.,et al.Submitted (JUN-2004) to the EMBL/GenBank/DDBJ databases.
Ota T.,et al.Nat. Genet. 36:40-45(2004).

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$ 395.00
Cat# ALS15009
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