|Application ||WB, IHC-P, E|
|Reactivity||Human, Mouse, Rat|
|Dilution||ELISA (1:5000), IHC-P (10 µg/ml), WB (1:500-1:1000)|
|Other Names||Dual specificity mitogen-activated protein kinase kinase 3, MAP kinase kinase 3, MAPKK 3, 22.214.171.124, MAPK/ERK kinase 3, MEK 3, Stress-activated protein kinase kinase 2, SAPK kinase 2, SAPKK-2, SAPKK2, MAP2K3, MEK3, MKK3, PRKMK3, SKK2|
|Target/Specificity||MKK3 (Ab-189) Antibody detects endogenous levels of total MKK3 protein.|
|Reconstitution & Storage||Store at -20°C for up to one year.|
|Precautions||MAP2K3 / MEK3 / MKK3 Antibody (aa173-222) is for research use only and not for use in diagnostic or therapeutic procedures.|
|Synonyms||MEK3, MKK3, PRKMK3, SKK2|
|Function||Dual specificity kinase. Is activated by cytokines and environmental stress in vivo. Catalyzes the concomitant phosphorylation of a threonine and a tyrosine residue in the MAP kinase p38. Part of a signaling cascade that begins with the activation of the adrenergic receptor ADRA1B and leads to the activation of MAPK14.|
|Tissue Location||Abundant expression is seen in the skeletal muscle. It is also widely expressed in other tissues|
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Provided below are standard protocols that you may find useful for product applications.
Dual specificity kinase. Is activated by cytokines and environmental stress in vivo. Catalyzes the concomitant phosphorylation of a threonine and a tyrosine residue in the MAP kinase p38.
Derijard B.,et al.Science 267:682-685(1995).
Moriguchi T.,et al.J. Biol. Chem. 271:26981-26988(1996).
Han J.,et al.Submitted (AUG-1996) to the EMBL/GenBank/DDBJ databases.
Ota T.,et al.Nat. Genet. 36:40-45(2004).
Raingeaud J.,et al.Mol. Cell. Biol. 16:1247-1255(1996).
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