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APAF1 / APAF-1 Antibody (aa289-338)

Rabbit Polyclonal Antibody

     
  • WB - APAF1 / APAF-1 Antibody (aa289-338) ALS15034
    Western blot of extracts from COLO205 cells, using APAF-1-ALT Antibody.
    detail
  • IHC - APAF1 / APAF-1 Antibody (aa289-338) ALS15034
    Anti-APAF1 / APAF-1 antibody IHC of human heart.
    detail
  • SPECIFICATION
  • CITATIONS
  • PROTOCOLS
  • BACKGROUND
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Product Information
Application
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • E=ELISA
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
WB, IHC-P, E
Primary Accession O14727
Reactivity Human
Host Rabbit
Clonality Polyclonal
Calculated MW 142kDa
Dilution ELISA (1:10000), IHC-P (10 µg/ml), WB (1:500-1:1000)
Additional Information
Gene ID 317
Other Names Apoptotic protease-activating factor 1, APAF-1, APAF1, KIAA0413
Target/Specificity APAF-1-ALT Antibody detects endogenous levels of total APAF-1-ALT protein.
Reconstitution & Storage Store at -20°C for up to one year.
PrecautionsAPAF1 / APAF-1 Antibody (aa289-338) is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Name APAF1 (HGNC:576)
Synonyms KIAA0413
Function Oligomeric Apaf-1 mediates the cytochrome c-dependent autocatalytic activation of pro-caspase-9 (Apaf-3), leading to the activation of caspase-3 and apoptosis. This activation requires ATP. Isoform 6 is less effective in inducing apoptosis.
Cellular Location Cytoplasm.
Tissue Location Ubiquitous. Highest levels of expression in adult spleen and peripheral blood leukocytes, and in fetal brain, kidney and lung. Isoform 1 is expressed in heart, kidney and liver
Volume 50 µl
Research Areas
Citations (0)
citation

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Background

Oligomeric Apaf-1 mediates the cytochrome c-dependent autocatalytic activation of pro-caspase-9 (Apaf-3), leading to the activation of caspase-3 and apoptosis. This activation requires ATP. Isoform 6 is less effective in inducing apoptosis.

References

Zou H.,et al.Cell 90:405-413(1997).
Hahn C.,et al.Biochem. Biophys. Res. Commun. 261:746-749(1999).
Saleh A.,et al.J. Biol. Chem. 274:17941-17945(1999).
Hu Y.,et al.EMBO J. 18:3586-3595(1999).
Ogawa T.,et al.Biochem. Biophys. Res. Commun. 306:537-543(2003).

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Discontinued
Cat# ALS15034
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