|Application ||WB, IHC-P, E|
|Reactivity||Human, Mouse, Rat|
|Dilution||ELISA (1:20000), IHC-P (10 µg/ml), WB (1:500-1:1000)|
|Other Names||Claudin-7, CLDN-7, CLDN7, CEPTRL2, CPETRL2|
|Target/Specificity||Claudin 7 Antibody detects endogenous levels of total Claudin 7 protein.|
|Reconstitution & Storage||Store at -20°C for up to one year.|
|Precautions||CLDN7 / Claudin 7 Antibody (aa162-211) is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||Plays a major role in tight junction-specific obliteration of the intercellular space.|
|Cellular Location||Cell membrane; Multi-pass membrane protein. Lateral cell membrane. Cell junction, tight junction. Note=Co- localizes with EPCAM at the lateral cell membrane and tight junction|
|Tissue Location||Expressed in kidney, lung and prostate. Isoform 1 seems to be predominant, except in some normal prostate samples, where isoform 2 is the major form. Down-regulated in breast cancers, including ductal carcinoma in situ (DCIS), lobular carcinoma in situ (LCIS) and invasive ductal carcinoma (IDC) (at protein level), as well as in several cancer cell lines. Loss of expression correlates with histological grade, occurring predominantly in high-grade lesions.|
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Plays a major role in tight junction-specific obliteration of the intercellular space.
Keen T.J.,et al.Submitted (SEP-1998) to the EMBL/GenBank/DDBJ databases.
Ota T.,et al.Nat. Genet. 36:40-45(2004).
Kalnine N.,et al.Submitted (MAY-2003) to the EMBL/GenBank/DDBJ databases.
Zody M.C.,et al.Nature 440:1045-1049(2006).
Mural R.J.,et al.Submitted (SEP-2005) to the EMBL/GenBank/DDBJ databases.
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