|Application ||WB, IHC-P, E|
|Reactivity||Human, Mouse, Rat|
|Dilution||ELISA (1:10000), IHC-P (10 µg/ml), WB (1:500-1:1000)|
|Other Names||Keratin, type I cytoskeletal 16, Cytokeratin-16, CK-16, Keratin-16, K16, KRT16, KRT16A|
|Target/Specificity||Keratin 16 Antibody detects endogenous levels of total Keratin 16 protein.|
|Reconstitution & Storage||Store at -20°C for up to one year.|
|Precautions||KRT16 / CK16 / Cytokeratin 16 Antibody (aa421-470) is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||Epidermis-specific type I keratin that plays a key role in skin. Acts as a regulator of innate immunity in response to skin barrier breach: required for some inflammatory checkpoint for the skin barrier maintenance.|
|Tissue Location||Expressed in the hair follicle, nail bed and in mucosal stratified squamous epithelia and, suprabasally, in oral epithelium and palmoplantar epidermis. Also found in luminal cells of sweat and mammary gland ducts|
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Provided below are standard protocols that you may find useful for product applications.
Epidermis-specific type I keratin that plays a key role in skin. Acts as a regulator of innate immunity in response to skin barrier breach: required for some inflammatory checkpoint for the skin barrier maintenance.
Raychaudhury A.,et al.Mol. Cell. Biol. 6:539-548(1986).
Rosenberg M.,et al.Mol. Cell. Biol. 8:722-736(1988).
Paladini R.D.,et al.Biochem. Biophys. Res. Commun. 215:517-523(1995).
Smith F.J.D.,et al.Submitted (APR-1998) to the EMBL/GenBank/DDBJ databases.
Ota T.,et al.Nat. Genet. 36:40-45(2004).
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