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>   home   >   Products   >   Primary Antibodies   >   Signal Transduction   >   CD172A / SIRPA Antibody (aa451-500)   

CD172A / SIRPA Antibody (aa451-500)

Rabbit Polyclonal Antibody

     
  • WB - CD172A / SIRPA Antibody (aa451-500) ALS15059
    Western blot of extracts from HepG2 cells, using Sirp alpha1 Antibody.
  • SPECIFICATION
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Product Information
Application
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • E=ELISA
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
WB, IHC-P, E
Primary Accession P78324
Reactivity Human, Mouse, Rat
Host Rabbit
Clonality Polyclonal
Calculated MW 55kDa
Dilution ELISA (1:20000), IHC-P (10 µg/ml), WB (1:500-1:1000)
Additional Information
Gene ID 140885
Other Names Tyrosine-protein phosphatase non-receptor type substrate 1, SHP substrate 1, SHPS-1, Brain Ig-like molecule with tyrosine-based activation motifs, Bit, CD172 antigen-like family member A, Inhibitory receptor SHPS-1, Macrophage fusion receptor, MyD-1 antigen, Signal-regulatory protein alpha-1, Sirp-alpha-1, Signal-regulatory protein alpha-2, Sirp-alpha-2, Signal-regulatory protein alpha-3, Sirp-alpha-3, p84, CD172a, SIRPA, BIT, MFR, MYD1, PTPNS1, SHPS1, SIRP
Target/Specificity Sirp alpha1 Antibody detects endogenous levels of total Sirp alpha1 protein.
Reconstitution & Storage Store at -20°C for up to one year.
PrecautionsCD172A / SIRPA Antibody (aa451-500) is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Name SIRPA
Synonyms BIT, MFR, MYD1, PTPNS1, SHPS1, SIRP
Function Immunoglobulin-like cell surface receptor for CD47. Acts as docking protein and induces translocation of PTPN6, PTPN11 and other binding partners from the cytosol to the plasma membrane. Supports adhesion of cerebellar neurons, neurite outgrowth and glial cell attachment. May play a key role in intracellular signaling during synaptogenesis and in synaptic function (By similarity). Involved in the negative regulation of receptor tyrosine kinase-coupled cellular responses induced by cell adhesion, growth factors or insulin. Mediates negative regulation of phagocytosis, mast cell activation and dendritic cell activation. CD47 binding prevents maturation of immature dendritic cells and inhibits cytokine production by mature dendritic cells.
Cellular Location Membrane; Single-pass type I membrane protein
Tissue Location Ubiquitous. Highly expressed in brain. Detected on myeloid cells, but not T-cells. Detected at lower levels in heart, placenta, lung, testis, ovary, colon, liver, small intestine, prostate, spleen, kidney, skeletal muscle and pancreas
Volume 50 µl
Research Areas
Citations (0)

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Background

Immunoglobulin-like cell surface receptor for CD47. Acts as docking protein and induces translocation of PTPN6, PTPN11 and other binding partners from the cytosol to the plasma membrane. Supports adhesion of cerebellar neurons, neurite outgrowth and glial cell attachment. May play a key role in intracellular signaling during synaptogenesis and in synaptic function (By similarity). Involved in the negative regulation of receptor tyrosine kinase-coupled cellular responses induced by cell adhesion, growth factors or insulin. Mediates negative regulation of phagocytosis, mast cell activation and dendritic cell activation. CD47 binding prevents maturation of immature dendritic cells and inhibits cytokine production by mature dendritic cells.

References

Yamao T.,et al.Biochem. Biophys. Res. Commun. 231:61-67(1997).
Kharitonenkov A.,et al.Nature 386:181-186(1997).
Sano S.,et al.Biochem. J. 344:667-675(1999).
Ota T.,et al.Nat. Genet. 36:40-45(2004).
Deloukas P.,et al.Nature 414:865-871(2001).

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$ 395.00
Cat# ALS15059
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