|Application ||WB, IHC-P, E|
|Reactivity||Human, Mouse, Rat|
|Dilution||ELISA (1:1000), IHC-P (10 µg/ml), WB (1:500-1:1000)|
|Other Names||Alpha-synuclein, Non-A beta component of AD amyloid, Non-A4 component of amyloid precursor, NACP, SNCA, NACP, PARK1|
|Target/Specificity||Synuclein Antibody detects endogenous levels of total Synuclein protein.|
|Reconstitution & Storage||Long term: -20°C; Short term: +4°C; Avoid freeze-thaw cycles.|
|Precautions||SNCA / Alpha-Synuclein Antibody (aa91-140) is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||May be involved in the regulation of dopamine release and transport. Induces fibrillization of microtubule-associated protein tau. Reduces neuronal responsiveness to various apoptotic stimuli, leading to a decreased caspase-3 activation.|
|Cellular Location||Cytoplasm, cytosol Membrane. Nucleus. Cell junction, synapse. Secreted. Note=Membrane-bound in dopaminergic neurons.|
|Tissue Location||Expressed principally in brain but is also expressed in low concentrations in all tissues examined except in liver. Concentrated in presynaptic nerve terminals|
email@example.com, and receive a free "I Love Antibodies" mug.
Provided below are standard protocols that you may find useful for product applications.
May be involved in the regulation of dopamine release and transport. Induces fibrillization of microtubule-associated protein tau. Reduces neuronal responsiveness to various apoptotic stimuli, leading to a decreased caspase-3 activation.
Ueda K.,et al.Proc. Natl. Acad. Sci. U.S.A. 90:11282-11286(1993).
Campion D.,et al.Genomics 26:254-257(1995).
Ueda K.,et al.Biochem. Biophys. Res. Commun. 205:1366-1372(1994).
Xia Y.,et al.Submitted (JAN-1996) to the EMBL/GenBank/DDBJ databases.
Touchman J.W.,et al.Genome Res. 11:78-86(2001).
If you have any additional inquiries please email technical services at firstname.lastname@example.org.