|Application ||IHC-P, E|
|Reactivity||Human, Mouse, Rat|
|Dilution||ELISA (1:1000), IHC-P (10 µg/ml),|
|Other Names||Phospholipase D1, PLD 1, hPLD1, 126.96.36.199, Choline phosphatase 1, Phosphatidylcholine-hydrolyzing phospholipase D1, PLD1|
|Target/Specificity||PLD1 Antibody detects endogenous levels of total PLD1 protein.|
|Reconstitution & Storage||Long term: -20°C; Short term: +4°C; Avoid freeze-thaw cycles.|
|Precautions||PLD1 / Phospholipase D1 Antibody (aa527-576) is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||Implicated as a critical step in numerous cellular pathways, including signal transduction, membrane trafficking, and the regulation of mitosis. May be involved in the regulation of perinuclear intravesicular membrane traffic (By similarity).|
|Cellular Location||Cytoplasm, perinuclear region. Endoplasmic reticulum membrane; Lipid-anchor; Cytoplasmic side. Golgi apparatus membrane; Lipid-anchor; Cytoplasmic side. Late endosome membrane; Lipid- anchor; Cytoplasmic side|
|Tissue Location||Expressed abundantly in the pancreas and heart and at high levels in brain, placenta, spleen, uterus and small intestine.|
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Implicated as a critical step in numerous cellular pathways, including signal transduction, membrane trafficking, and the regulation of mitosis. May be involved in the regulation of perinuclear intravesicular membrane traffic (By similarity).
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Hammond S.M.,et al.J. Biol. Chem. 272:3860-3868(1997).
Steed P.M.,et al.FASEB J. 12:1309-1317(1998).
Hughes W.E.,et al.Submitted (FEB-2000) to the EMBL/GenBank/DDBJ databases.
Lopez I.,et al.J. Biol. Chem. 273:12846-12852(1998).
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