|Application ||IHC-P, E|
|Reactivity||Human, Mouse, Rat|
|Dilution||ELISA (1:1000), IHC-P (10 µg/ml),|
|Other Names||Phospholipase D1, PLD 1, hPLD1, 188.8.131.52, Choline phosphatase 1, Phosphatidylcholine-hydrolyzing phospholipase D1, PLD1|
|Target/Specificity||PLD1 Antibody detects endogenous levels of total PLD1 protein.|
|Reconstitution & Storage||Long term: -20°C; Short term: +4°C; Avoid freeze-thaw cycles.|
|Precautions||PLD1 / Phospholipase D1 Antibody (aa527-576) is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||Implicated as a critical step in numerous cellular pathways, including signal transduction, membrane trafficking, and the regulation of mitosis. May be involved in the regulation of perinuclear intravesicular membrane traffic (By similarity).|
|Cellular Location||Cytoplasm, perinuclear region. Endoplasmic reticulum membrane; Lipid-anchor; Cytoplasmic side. Golgi apparatus membrane; Lipid-anchor; Cytoplasmic side. Late endosome membrane; Lipid- anchor; Cytoplasmic side|
|Tissue Location||Expressed abundantly in the pancreas and heart and at high levels in brain, placenta, spleen, uterus and small intestine.|
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Provided below are standard protocols that you may find useful for product applications.
Implicated as a critical step in numerous cellular pathways, including signal transduction, membrane trafficking, and the regulation of mitosis. May be involved in the regulation of perinuclear intravesicular membrane traffic (By similarity).
Hammond S.M.,et al.J. Biol. Chem. 270:29640-29643(1995).
Hammond S.M.,et al.J. Biol. Chem. 272:3860-3868(1997).
Steed P.M.,et al.FASEB J. 12:1309-1317(1998).
Hughes W.E.,et al.Submitted (FEB-2000) to the EMBL/GenBank/DDBJ databases.
Lopez I.,et al.J. Biol. Chem. 273:12846-12852(1998).
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