PTP1B Antibody (aa16-65)
Rabbit Polyclonal Antibody
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Application
| WB, IHC-P, E |
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Primary Accession | P18031 |
Reactivity | Human, Mouse, Rat |
Host | Rabbit |
Clonality | Polyclonal |
Calculated MW | 50kDa |
Dilution | ELISA (1:20000), IHC-P (10 µg/ml), WB (1:500-1:1000) |
Gene ID | 5770 |
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Other Names | Tyrosine-protein phosphatase non-receptor type 1, 3.1.3.48, Protein-tyrosine phosphatase 1B, PTP-1B, PTPN1, PTP1B |
Target/Specificity | PTP1B Antibody detects endogenous levels of total PTP1B protein. |
Reconstitution & Storage | Long term: -20°C; Short term: +4°C; Avoid freeze-thaw cycles. |
Precautions | PTP1B Antibody (aa16-65) is for research use only and not for use in diagnostic or therapeutic procedures. |
Name | PTPN1 |
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Synonyms | PTP1B |
Function | Tyrosine-protein phosphatase which acts as a regulator of endoplasmic reticulum unfolded protein response. Mediates dephosphorylation of EIF2AK3/PERK; inactivating the protein kinase activity of EIF2AK3/PERK. May play an important role in CKII- and p60c- src-induced signal transduction cascades. May regulate the EFNA5-EPHA3 signaling pathway which modulates cell reorganization and cell-cell repulsion. May also regulate the hepatocyte growth factor receptor signaling pathway through dephosphorylation of MET. |
Cellular Location | Endoplasmic reticulum membrane; Peripheral membrane protein; Cytoplasmic side Note=Interacts with EPHA3 at the cell membrane |
Tissue Location | Expressed in keratinocytes (at protein level). |
Volume | 50 µl |
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Provided below are standard protocols that you may find useful for product applications.
Background
Tyrosine-protein phosphatase which acts as a regulator of endoplasmic reticulum unfolded protein response. Mediates dephosphorylation of EIF2AK3/PERK; inactivating the protein kinase activity of EIF2AK3/PERK. May play an important role in CKII- and p60c-src-induced signal transduction cascades. May regulate the EFNA5-EPHA3 signaling pathway which modulates cell reorganization and cell-cell repulsion. May also regulate the hepatocyte growth factor receptor signaling pathway through dephosphorylation of MET.
References
Chernoff J.,et al.Proc. Natl. Acad. Sci. U.S.A. 87:2735-2739(1990).
Brown-Shimer S.,et al.Proc. Natl. Acad. Sci. U.S.A. 87:5148-5152(1990).
Kalnine N.,et al.Submitted (MAY-2003) to the EMBL/GenBank/DDBJ databases.
Deloukas P.,et al.Nature 414:865-871(2001).
Charbonneau H.,et al.Proc. Natl. Acad. Sci. U.S.A. 86:5252-5256(1989).
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