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>   home   >   Products   >   Primary Antibodies   >   PIAS4 / PIASY Antibody (aa451-500)   

PIAS4 / PIASY Antibody (aa451-500)

Rabbit Polyclonal Antibody

     
  • WB - PIAS4 / PIASY Antibody (aa451-500) ALS15081
    Western blot of extracts from Jurkat cells, using PIAS4 Antibody.
  • SPECIFICATION
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Product Information
Application
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • E=ELISA
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
WB, IHC-P, E
Primary Accession Q8N2W9
Reactivity Human, Mouse
Host Rabbit
Clonality Polyclonal
Calculated MW 57kDa
Dilution ELISA (1:20000), IHC-P (10 µg/ml), WB (1:500-1:1000)
Additional Information
Gene ID 51588
Other Names E3 SUMO-protein ligase PIAS4, 6.3.2.-, PIASy, Protein inhibitor of activated STAT protein 4, Protein inhibitor of activated STAT protein gamma, PIAS-gamma, PIAS4, PIASG
Target/Specificity PIAS4 Antibody detects endogenous levels of total PIAS4 protein.
Reconstitution & Storage Store at -20°C for up to one year.
PrecautionsPIAS4 / PIASY Antibody (aa451-500) is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Name PIAS4
Synonyms PIASG
Function Functions as an E3-type small ubiquitin-like modifier (SUMO) ligase, stabilizing the interaction between UBE2I and the substrate, and as a SUMO-tethering factor. Plays a crucial role as a transcriptional coregulation in various cellular pathways, including the STAT pathway, the p53/TP53 pathway, the Wnt pathway and the steroid hormone signaling pathway. Involved in gene silencing. Mediates sumoylation of CEBPA, PARK7, HERC2, MYB, TCF4 and RNF168. In Wnt signaling, represses LEF1 and enhances TCF4 transcriptional activities through promoting their sumoylations. Enhances the sumoylation of MTA1 and may participate in its paralog-selective sumoylation.
Cellular Location Nucleus, PML body. Note=Colocalizes with SUMO1 and TCF7L2/TCF4 and LEF1 in a subset of PML (promyelocytic leukemia) nuclear bodies
Tissue Location Highly expressed in testis and, at lower levels, in spleen, prostate, ovary, colon and peripheral blood leukocytes.
Volume 50 µl
Citations (0)

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Background

Functions as an E3-type small ubiquitin-like modifier (SUMO) ligase, stabilizing the interaction between UBE2I and the substrate, and as a SUMO-tethering factor. Plays a crucial role as a transcriptional coregulation in various cellular pathways, including the STAT pathway, the p53/TP53 pathway, the Wnt pathway and the steroid hormone signaling pathway. Involved in gene silencing. Mediates sumoylation of CEBPA, PARK7, HERC2, MYB, TCF4 and RNF168. In Wnt signaling, represses LEF1 and enhances TCF4 transcriptional activities through promoting their sumoylations. Enhances the sumoylation of MTA1 and may participate in its paralog-selective sumoylation.

References

Liu B.,et al.Proc. Natl. Acad. Sci. U.S.A. 95:10626-10631(1998).
Nelson V.,et al.Apoptosis 6:221-234(2001).
Liu B.,et al.Proc. Natl. Acad. Sci. U.S.A. 98:3203-3207(2001).
Gross M.,et al.Oncogene 20:3880-3887(2001).
Rui H.L.,et al.J. Biol. Chem. 277:42981-42986(2002).

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$ 395.00
Cat# ALS15081
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