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SAE2 / UBA2 Antibody (aa591-640)

Rabbit Polyclonal Antibody

     
  • WB - SAE2 / UBA2 Antibody (aa591-640) ALS15087
    Western blot of extracts from 293 cells, treated with UV 5', using Uba2 Antibody.
  • IHC - SAE2 / UBA2 Antibody (aa591-640) ALS15087
    Anti-UBA2 antibody IHC of human testis.
  • SPECIFICATION
  • CITATIONS
  • PROTOCOLS
  • BACKGROUND
Product Information
Application
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • E=ELISA
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
WB, IHC-P, E
Primary Accession Q9UBT2
Reactivity Human
Host Rabbit
Clonality Polyclonal
Calculated MW 71kDa
Dilution ELISA (1:5000), IHC-P (10 µg/ml), WB (1:500-1:1000)
Additional Information
Gene ID 10054
Other Names SUMO-activating enzyme subunit 2, 6.3.2.-, Anthracycline-associated resistance ARX, Ubiquitin-like 1-activating enzyme E1B, Ubiquitin-like modifier-activating enzyme 2, UBA2, SAE2, UBLE1B
Target/Specificity Uba2 Antibody detects endogenous levels of total Uba2 protein.
Reconstitution & Storage Store at -20°C for up to one year.
PrecautionsSAE2 / UBA2 Antibody (aa591-640) is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Name UBA2
Synonyms SAE2, UBLE1B
Function The heterodimer acts as an E1 ligase for SUMO1, SUMO2, SUMO3, and probably SUMO4. It mediates ATP-dependent activation of SUMO proteins followed by formation of a thioester bond between a SUMO protein and a conserved active site cysteine residue on UBA2/SAE2.
Cellular Location Cytoplasm. Nucleus. Note=Shuttles between the cytoplasm and the nucleus, sumoylation is required either for nuclear translocation or nuclear retention
Volume 50 µl
Research Areas
Citations (0)

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Background

The heterodimer acts as a E1 ligase for SUMO1, SUMO2, SUMO3, and probably SUMO4. It mediates ATP-dependent activation of SUMO proteins followed by formation of a thioester bond between a SUMO protein and a conserved active site cysteine residue on UBA2/SAE2.

References

Okuma T.,et al.Biochem. Biophys. Res. Commun. 254:693-698(1999).
Gong L.,et al.FEBS Lett. 448:185-189(1999).
Desterro J.M.P.,et al.J. Biol. Chem. 274:10618-10624(1999).
Slapak C.,et al.Submitted (SEP-1995) to the EMBL/GenBank/DDBJ databases.
Wiemann S.,et al.Genome Res. 11:422-435(2001).

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$ 395.00
Cat# ALS15087
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