|Application ||WB, IHC-P, E|
|Dilution||ELISA (1:10000), IHC-P (10 µg/ml), WB (1:500-1:1000)|
|Other Names||Ubiquitin-like modifier-activating enzyme 7, Ubiquitin-activating enzyme 7, D8, Ubiquitin-activating enzyme E1 homolog, UBA7, UBE1L, UBE2|
|Target/Specificity||UBE1L Antibody detects endogenous levels of total UBE1L protein.|
|Reconstitution & Storage||Store at -20°C for up to one year.|
|Precautions||UBE1L / UBA7 Antibody (aa963-1012) is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||Activates ubiquitin by first adenylating with ATP its C- terminal glycine residue and thereafter linking this residue to the side chain of a cysteine residue in E1, yielding a ubiquitin- E1 thioester and free AMP. Catalyzes the ISGylation of influenza A virus NS1 protein.|
|Tissue Location||Expressed in a variety of normal and tumor cell types, but is reduced in lung cancer cell lines|
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Provided below are standard protocols that you may find useful for product applications.
Activates ubiquitin by first adenylating with ATP its C- terminal glycine residue and thereafter linking this residue to the side chain of a cysteine residue in E1, yielding a ubiquitin- E1 thioester and free AMP. Catalyzes the ISGylation of influenza A virus NS1 protein.
Kok K.,et al.Proc. Natl. Acad. Sci. U.S.A. 90:6071-6075(1993).
Kok K.,et al.Gene Expr. 4:163-175(1995).
Kalnine N.,et al.Submitted (MAY-2003) to the EMBL/GenBank/DDBJ databases.
Mural R.J.,et al.Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases.
Gevaert K.,et al.Nat. Biotechnol. 21:566-569(2003).
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