|Application ||WB, IHC-P, E|
|Dilution||ELISA (1:1000), IHC-P (10 µg/ml), WB (1:500-1:1000)|
|Other Names||Caspase-2, CASP-2, 220.127.116.11, Neural precursor cell expressed developmentally down-regulated protein 2, NEDD-2, Protease ICH-1, Caspase-2 subunit p18, Caspase-2 subunit p13, Caspase-2 subunit p12, CASP2, ICH1, NEDD2|
|Target/Specificity||Caspase 2 Antibody detects endogenous levels of total Caspase 2 protein.|
|Reconstitution & Storage||Long term: -20°C; Short term: +4°C; Avoid freeze-thaw cycles.|
|Precautions||CASP2 / Caspase 2 Antibody (aa123-172) is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||Involved in the activation cascade of caspases responsible for apoptosis execution. Might function by either activating some proteins required for cell death or inactivating proteins necessary for cell survival.|
|Tissue Location||Expressed at higher levels in the embryonic lung, liver and kidney than in the heart and brain. In adults, higher level expression is seen in the placenta, lung, kidney, and pancreas than in the heart, brain, liver and skeletal muscle|
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Involved in the activation cascade of caspases responsible for apoptosis execution. Might function by either activating some proteins required for cell death or inactivating proteins necessary for cell survival.
Wang L.,et al.Cell 78:739-750(1994).
Droin N.,et al.Cancer Res. 60:7039-7047(2000).
Halleck A.,et al.Submitted (JUN-2004) to the EMBL/GenBank/DDBJ databases.
Ota T.,et al.Nat. Genet. 36:40-45(2004).
Hillier L.W.,et al.Nature 424:157-164(2003).
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