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CASP2 / Caspase 2 Antibody (aa123-172)

Rabbit Polyclonal Antibody

     
  • WB - CASP2 / Caspase 2 Antibody (aa123-172) ALS15090
    Western blot of extracts from K562, using Caspase 2 Antibody.
    detail
  • SPECIFICATION
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Product Information
Application
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • E=ELISA
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
WB, IHC-P, E
Primary Accession P42575
Reactivity Human
Host Rabbit
Clonality Polyclonal
Calculated MW 51kDa
Dilution ELISA (1:1000), IHC-P (10 µg/ml), WB (1:500-1:1000)
Additional Information
Gene ID 835
Other Names Caspase-2, CASP-2, 3.4.22.55, Neural precursor cell expressed developmentally down-regulated protein 2, NEDD-2, Protease ICH-1, Caspase-2 subunit p18, Caspase-2 subunit p13, Caspase-2 subunit p12, CASP2, ICH1, NEDD2
Target/Specificity Caspase 2 Antibody detects endogenous levels of total Caspase 2 protein.
Reconstitution & Storage Long term: -20°C; Short term: +4°C; Avoid freeze-thaw cycles.
PrecautionsCASP2 / Caspase 2 Antibody (aa123-172) is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Name CASP2
Synonyms ICH1, NEDD2
Function Involved in the activation cascade of caspases responsible for apoptosis execution. Might function by either activating some proteins required for cell death or inactivating proteins necessary for cell survival (PubMed:15073321). Associates with PIDD1 and CRADD to form the PIDDosome, a complex that activates CASP2 and triggers apoptosis in response to genotoxic stress (PubMed:15073321).
Tissue Location Expressed at higher levels in the embryonic lung, liver and kidney than in the heart and brain. In adults, higher level expression is seen in the placenta, lung, kidney, and pancreas than in the heart, brain, liver and skeletal muscle
Volume 50 µl
Research Areas
Citations (0)
citation

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Background

Involved in the activation cascade of caspases responsible for apoptosis execution. Might function by either activating some proteins required for cell death or inactivating proteins necessary for cell survival.

References

Wang L.,et al.Cell 78:739-750(1994).
Droin N.,et al.Cancer Res. 60:7039-7047(2000).
Halleck A.,et al.Submitted (JUN-2004) to the EMBL/GenBank/DDBJ databases.
Ota T.,et al.Nat. Genet. 36:40-45(2004).
Hillier L.W.,et al.Nature 424:157-164(2003).

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Discontinued
Cat# ALS15090
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