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>   home   >   Products   >   Primary Antibodies   >   Neuroscience   >   HEP / EPHB6 Antibody (aa861-910)   

HEP / EPHB6 Antibody (aa861-910)

Rabbit Polyclonal Antibody

     
  • IF - HEP / EPHB6 Antibody (aa861-910) ALS15097
    Immunofluorescence of HeLa cells, using EPHB6 Antibody.
  • WB - HEP / EPHB6 Antibody (aa861-910) ALS15097
    Western blot of extracts from COLO/293/HeLa cells, using EPHB6 Antibody.
  • IHC - HEP / EPHB6 Antibody (aa861-910) ALS15097
    Anti-EPHB6 antibody IHC of human breast.
  • SPECIFICATION
  • CITATIONS
  • PROTOCOLS
  • BACKGROUND
Product Information
Application
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • E=ELISA
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
WB, IHC-P, IF, E
Primary Accession O15197
Reactivity Human, Mouse, Rat
Host Rabbit
Clonality Polyclonal
Calculated MW 111kDa
Dilution ELISA (1:1000), IF (1:100-1:500), IHC-P (10 µg/ml), WB (1:500-1:1000) ,
Additional Information
Gene ID 2051
Other Names Ephrin type-B receptor 6, HEP, Tyrosine-protein kinase-defective receptor EPH-6, EPHB6
Target/Specificity EPHB6 Antibody detects endogenous levels of total EPHB6 protein.
Reconstitution & Storage Store at -20°C for up to one year.
PrecautionsHEP / EPHB6 Antibody (aa861-910) is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Name EPHB6
Function Kinase-defective receptor for members of the ephrin-B family. Binds to ephrin-B1 and ephrin-B2. Modulates cell adhesion and migration by exerting both positive and negative effects upon stimulation with ephrin-B2. Inhibits JNK activation, T-cell receptor-induced IL-2 secretion and CD25 expression upon stimulation with ephrin-B2.
Cellular Location Membrane; Single-pass type I membrane protein
Tissue Location Expressed in brain. Expressed in non invasive breast carcinoma cell lines (at protein level). Strong expression in brain and pancreas, and weak expression in other tissues, such as heart, placenta, lung, liver, skeletal muscle and kidney Expressed in breast non invasive tumors but not in metastatic lesions. Isoform 3 is expressed in cell lines of glioblastomas, anaplastic astrocytomas, gliosarcomas and astrocytomas. Isoform 3 is not detected in normal tissues.
Volume 50 µl
Research Areas
Citations (0)

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Background

Kinase-defective receptor for members of the ephrin-B family. Binds to ephrin-B1 and ephrin-B2. Modulates cell adhesion and migration by exerting both positive and negative effects upon stimulation with ephrin-B2. Inhibits JNK activation, T-cell receptor-induced IL-2 secretion and CD25 expression upon stimulation with ephrin-B2.

References

Matsuoka H.,et al.Biochem. Biophys. Res. Commun. 235:487-492(1997).
Hillier L.W.,et al.Nature 424:157-164(2003).
Scherer S.W.,et al.Science 300:767-772(2003).
Mural R.J.,et al.Submitted (SEP-2005) to the EMBL/GenBank/DDBJ databases.
Jin M.,et al.Oncol. Rep. 19:1277-1283(2008).

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$ 395.00
Cat# ALS15097
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