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>   home   >   Products   >   Primary Antibodies   >   Microbiology   >   HCF1 / HCFC1 Antibody (aa131-180)   

HCF1 / HCFC1 Antibody (aa131-180)

Rabbit Polyclonal Antibody

     
  • IHC - HCF1 / HCFC1 Antibody (aa131-180) ALS15106
    Anti-HCFC1 / HCF-1 antibody IHC of human tonsil.
  • SPECIFICATION
  • CITATIONS
  • PROTOCOLS
  • BACKGROUND
Product Information
Application
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • E=ELISA
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
IHC-P, E
Primary Accession P51610
Reactivity Human, Mouse
Host Rabbit
Clonality Polyclonal
Calculated MW 209kDa
Dilution ELISA (1:20000), IHC-P (10 µg/ml),
Additional Information
Gene ID 3054
Other Names Host cell factor 1, HCF, HCF-1, C1 factor, CFF, VCAF, VP16 accessory protein, HCF N-terminal chain 1, HCF N-terminal chain 2, HCF N-terminal chain 3, HCF N-terminal chain 4, HCF N-terminal chain 5, HCF N-terminal chain 6, HCF C-terminal chain 1, HCF C-terminal chain 2, HCF C-terminal chain 3, HCF C-terminal chain 4, HCF C-terminal chain 5, HCF C-terminal chain 6, HCFC1, HCF1, HFC1
Target/Specificity HCFC1 Antibody detects endogenous levels of total HCFC1 protein.
Reconstitution & Storage Store at -20°C for up to one year.
PrecautionsHCF1 / HCFC1 Antibody (aa131-180) is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Name HCFC1
Synonyms HCF1, HFC1
Function Involved in control of the cell cycle. Also antagonizes transactivation by ZBTB17 and GABP2; represses ZBTB17 activation of the p15(INK4b) promoter and inhibits its ability to recruit p300. Coactivator for EGR2 and GABP2. Tethers the chromatin modifying Set1/Ash2 histone H3 'Lys-4' methyltransferase (H3K4me) and Sin3 histone deacetylase (HDAC) complexes (involved in the activation and repression of transcription, respectively) together. Component of a THAP1/THAP3-HCFC1-OGT complex that is required for the regulation of the transcriptional activity of RRM1. As part of the NSL complex it may be involved in acetylation of nucleosomal histone H4 on several lysine residues. In case of human herpes simplex virus (HSV) infection, HCFC1 forms a multiprotein-DNA complex with the viral transactivator protein VP16 and POU2F1 thereby enabling the transcription of the viral immediate early genes.
Cellular Location Cytoplasm. Nucleus. Note=HCFC1R1 modulates its subcellular localization and overexpression of HCFC1R1 leads to accumulation of HCFC1 in the cytoplasm. Nuclear in general, but uniquely cytoplasmic in trigeminal ganglia, becoming nuclear upon HSV reactivation from the latent state. Non-processed HCFC1 associates with chromatin. Colocalizes with CREB3 and CANX in the ER
Tissue Location Highly expressed in fetal tissues and the adult kidney. Present in all tissues tested
Volume 50 µl
Research Areas
Citations (0)

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Background

Involved in control of the cell cycle. Also antagonizes transactivation by ZBTB17 and GABP2; represses ZBTB17 activation of the p15(INK4b) promoter and inhibits its ability to recruit p300. Coactivator for EGR2 and GABP2. Tethers the chromatin modifying Set1/Ash2 histone H3 'Lys-4' methyltransferase (H3K4me) and Sin3 histone deacetylase (HDAC) complexes (involved in the activation and repression of transcription, respectively) together. Component of a THAP1/THAP3-HCFC1-OGT complex that is required for the regulation of the transcriptional activity of RRM1. As part of the NSL complex it may be involved in acetylation of nucleosomal histone H4 on several lysine residues. In case of human herpes simplex virus (HSV) infection, HCFC1 forms a multiprotein-DNA complex with the viral transactivator protein VP16 and POU2F1 thereby enabling the transcription of the viral immediate early genes.

References

Wilson A.C.,et al.Cell 74:115-125(1993).
Kristie T.M.,et al.J. Biol. Chem. 270:4387-4394(1995).
Ross M.T.,et al.Nature 434:325-337(2005).
Frattini A.,et al.Genomics 23:30-35(1994).
Vogel J.L.,et al.Proc. Natl. Acad. Sci. U.S.A. 97:9425-9430(2000).

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$ 395.00
Cat# ALS15106
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